FANCM is named after Fanconi anemia (FA) complement group M. The clinical symptoms of FA include congenital abnormalities, pancytopenia, and cancer proneness. However, recent studies reveal that biallelic inactivation of FANCM does not cause the constellation of FA symptoms, but predisposes patients to cancer and infertility. FANCM is a tumor suppressor gene that encodes a conserved and structure-specific DNA translocase. It controls the outcome of homologous recombination and facilitates DNA replication across a variety of natural and chemically induced obstacles. This review details our current understanding of FANCM as a facilitator of the cellular functions of caretaker proteins, including FA, Bloom syndrome, and Ataxia telangiectasia and RAD3-related proteins, which collectively ensure the maintenance of chromosome stability during DNA replication.

FANCM以Fanconi贫血（FA）补体M组命名。FA的临床症状包括先天性异常，全血细胞减少和癌变倾向。但是，最近的研究表明，FANCM的双等位基因失活不会引起FA症状，但会使患者更易患癌症和不育症。FANCM是一种肿瘤抑制基因，编码保守的和结构特异性的DNA转位酶。它控制同源重组的结果，并促进DNA在各种自然和化学诱导的障碍物之间的复制。这篇评论详述了我们目前对FANCM作为看守蛋白（包括FA，Bloom综合征，共济失调毛细血管扩张症和RAD3相关蛋白）的细胞功能的促进者的理解，