Although relatively small in size, the ZZ-type zinc finger (ZZ) domain is a versatile signaling module that is implicated in a diverse set of cell signaling events. Here, we highlight the most recent studies focused on the ZZ domain function as a histone reader and a sensor of protein degradation signals. We review and compare the molecular and structural mechanisms underlying targeting the amino-terminal sequences of histone H3 and arginylated substrates by the ZZ domain. We also discuss the ZZ domain sensitivity to histone PTMs and summarize biological outcomes associated with the recognition of histone and non-histone ligands by the ZZ domain-containing proteins and complexes.

尽管大小相对较小，但ZZ型锌指（ZZ）域是一种通用的信号模块，与多种细胞信号事件有关。在这里，我们重点介绍专注于ZZ域作为组蛋白读取器和蛋白质降解信号传感器的最新研究。我们审查和比较通过ZZ域靶向组蛋白H3和精氨酸底物的氨基末端序列的分子和结构机制。我们还将讨论ZZ域对组蛋白PTM的敏感性，并总结与含ZZ域的蛋白和复合物识别组蛋白和非组蛋白配体有关的生物学结果。