The current problem of increasing antibiotic resistance and the resurgence of numerous infections indicate the need for novel vaccination strategies more than ever. In vaccine development, the search for and the selection of adequate vaccine antigens is the first important step. In recent years, bacterial outer membrane proteins have become of major interest, as they are the main proteins interacting with the extracellular environment. Trimeric autotransporter adhesins (TAAs) are important virulence factors in many Gram-negative bacteria, are localised on the bacterial surface, and mediate the first adherence to host cells in the course of infection. One example is the Neisseria adhesin A (NadA), which is currently used as a subunit in a licensed vaccine against Neisseria meningitidis. Other TAAs that seem promising vaccine candidates are the Acinetobacter trimeric autotransporter (Ata), the Haemophilus influenzae adhesin (Hia), and TAAs of the genus Bartonella. Here, we review the suitability of various TAAs as vaccine candidates.

中文翻译：

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三聚体自转运蛋白粘附素的免疫原性及其作为疫苗靶点的潜力。

当前抗生素耐药性增加和大量感染复发的问题表明比以往任何时候都更需要新的疫苗接种策略。在疫苗开发中，寻找和选择足够的疫苗抗原是第一个重要步骤。近年来，细菌外膜蛋白引起了人们的广泛兴趣，因为它们是与细胞外环境相互作用的主要蛋白质。三聚体自转运蛋白粘附素（TAA）是许多革兰氏阴性细菌中重要的毒力因子，位于细菌表面，并在感染过程中介导对宿主细胞的首次粘附。一个例子是奈瑟氏菌粘附素 A (NadA)，目前它被用作一种获得许可的脑膜炎奈瑟氏菌疫苗的亚基。其他看起来有希望的候选疫苗 TAA 包括不动杆菌三聚体自转运蛋白 (Ata)、流感嗜血杆菌粘附素 (Hia) 和巴尔通体属的 TAA 。在这里，我们回顾了各种 TAA 作为候选疫苗的适用性。