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Triterpenoids from Ainsliaea latifolia and Their Cyclooxyenase-2 (COX-2) Inhibitory Activities.
Natural Products and Bioprospecting Pub Date : 2019-11-30 , DOI: 10.1007/s13659-019-00228-x Wen-Lin Yuan 1 , Xue-Yun Dong 1, 2 , Zheng-Rui Huang 3 , Si-Jia Xiao 1 , Ji Ye 1 , Xin-Hui Tian 4 , Hui-Liang Li 1 , Yun-Heng Shen 1 , Wei-Dong Zhang 1, 4
中文翻译:
阔叶冬青的三萜类化合物及其环氧合酶-2(COX-2)抑制活性。
更新日期:2019-11-30
Natural Products and Bioprospecting Pub Date : 2019-11-30 , DOI: 10.1007/s13659-019-00228-x Wen-Lin Yuan 1 , Xue-Yun Dong 1, 2 , Zheng-Rui Huang 3 , Si-Jia Xiao 1 , Ji Ye 1 , Xin-Hui Tian 4 , Hui-Liang Li 1 , Yun-Heng Shen 1 , Wei-Dong Zhang 1, 4
Affiliation
Abstract
Eight new triterpenoids were isolated from Ainsliaea latifolia. The structures of these compounds were elucidated by interpretation of spectroscopic data, including HRESIMS and NMR data. Compounds 4–6 are identified as rare trinorcucurbitane or tetranorcucurbitane triterpenoids. The absolute configurations of compounds 1 and 2 were confirmed by Snatzke’s method. All compounds were evaluated for their inhibition against cyclooxyenase-2 (COX-2), in which compound 4 showed significant inhibitory effect against COX-2 with IC50 value of 3.98 ± 0.32 μM, comparable to that of positive control NS-398 (IC50 4.14 ± 0.28 μM).Graphic Abstract
中文翻译:
阔叶冬青的三萜类化合物及其环氧合酶-2(COX-2)抑制活性。