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Triterpenoids from Ainsliaea latifolia and Their Cyclooxyenase-2 (COX-2) Inhibitory Activities.
Natural Products and Bioprospecting Pub Date : 2019-11-30 , DOI: 10.1007/s13659-019-00228-x
Wen-Lin Yuan 1 , Xue-Yun Dong 1, 2 , Zheng-Rui Huang 3 , Si-Jia Xiao 1 , Ji Ye 1 , Xin-Hui Tian 4 , Hui-Liang Li 1 , Yun-Heng Shen 1 , Wei-Dong Zhang 1, 4
Affiliation  

Abstract

Eight new triterpenoids were isolated from Ainsliaea latifolia. The structures of these compounds were elucidated by interpretation of spectroscopic data, including HRESIMS and NMR data. Compounds 46 are identified as rare trinorcucurbitane or tetranorcucurbitane triterpenoids. The absolute configurations of compounds 1 and 2 were confirmed by Snatzke’s method. All compounds were evaluated for their inhibition against cyclooxyenase-2 (COX-2), in which compound 4 showed significant inhibitory effect against COX-2 with IC50 value of 3.98 ± 0.32 μM, comparable to that of positive control NS-398 (IC50 4.14 ± 0.28 μM).

Graphic Abstract



中文翻译:

阔叶冬青的三萜类化合物及其环氧合酶-2(COX-2)抑制活性。

摘要

海枣中分离出八种新的三萜通过解释光谱数据(包括HRESIMS和NMR数据)阐明了这些化合物的结构。化合物4 - 6被鉴定为稀有trinorcucurbitane或tetranorcucurbitane三萜类化合物。化合物12的绝对构型通过Snatzke方法证实。评估了所有化合物对环氧合酶2(COX-2)的抑制作用,其中化合物4对COX-2表现出明显的抑制作用,IC 50值为3.98±0.32μM,与阳性对照NS-398(IC 50 4.14±0.28μM)。

图形摘要

更新日期:2019-11-30
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