Acute upper gastrointestinal bleeding (UGIB) remains a public health burden with a persistent high mortality despite advances in modern day management. Proton pump inhibitors (PPI) as medical therapy is an attractive adjuvant to endoscopic treatment in UGIB but the method and dose of PPI therapy remains controversial. This chapter aims to describe the current evidence addressing acute PPI use in the management of UGIB. It will explore the evidence behind the timing, the dosage and the mode of administration of PPI during initial UGIB management, prior to and immediately following endoscopy, as well as in the short-term following discharge.

中文翻译：

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质子泵抑制剂用于上消化道出血。

尽管现代管理方法不断进步，但急性上消化道出血（UGIB）仍然是公共卫生负担，并且死亡率持续居高不下。质子泵抑制剂（PPI）作为药物治疗是UGIB内镜治疗的有吸引力的佐剂，但PPI治疗的方法和剂量仍有争议。本章旨在描述针对UGIB管理中急性PPI使用的最新证据。它将探索在初始UGIB治疗期间，内窥镜检查之前和之后以及在出院后短期内PPI的时机，剂量和给药方式背后的证据。