Quantification of brain proton longitudinal relaxation (T1) in lithium‐treated and lithium‐naïve patients with bipolar disorder in comparison to healthy controls,Bipolar Disorders

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Quantification of brain proton longitudinal relaxation (T1) in lithium‐treated and lithium‐naïve patients with bipolar disorder in comparison to healthy controls
Bipolar Disorders ( IF 5.4 ) Pub Date : 2019-11-21 , DOI: 10.1111/bdi.12878
Joe Necus _{1,

2} , Fiona Elizabeth Smith _{1,

3} , Peter Edward Thelwall _{1,

3} , Carly Jay Flowers ₁ , Nishant Sinha _{1,

2} , Peter Neal Taylor _{1,

2,

4} , Andrew Matthew Blamire _{1,

3} , Yujiang Wang _{1,

2,

4} , David Andrew Cousins _{1,

5}

Affiliation

Proton longitudinal relaxation (T₁) is a quantitative MRI‐derived tissue parameter sensitive to myelin, macromolecular, iron and water content. There is some evidence to suggest that cortical T₁ is elevated in bipolar disorder and that lithium administration reduces cortical T₁. However, T₁ has not yet been quantified in separate groups containing lithium‐treated patients, lithium‐naïve patients, and matched healthy controls.

中文翻译：

与健康对照组相比，锂治疗和未使用锂的双相情感障碍患者的脑质子纵向弛豫 (T1) 量化

质子纵向弛豫 (T ₁ ) 是 MRI 衍生的对髓磷脂、大分子、铁和水含量敏感的定量组织参数。有一些证据表明，双相情感障碍患者的皮层 T ₁升高，而锂给药降低了皮层 T ₁。然而，在包含锂治疗患者、锂初治患者和匹配的健康对照的不同组中，T ₁尚未量化。

更新日期：2019-11-21

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