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Differential patterns of alcohol and nicotine intake: Combined alcohol and nicotine binge consumption behaviors in mice.
Alcohol ( IF 2.3 ) Pub Date : 2019-09-23 , DOI: 10.1016/j.alcohol.2019.09.006
Margot C DeBaker 1 , Jenna M Robinson 2 , Janna K Moen 1 , Kevin Wickman 2 , Anna M Lee 2
Affiliation  

Late adolescence and young adulthood, corresponding to the high school and college years, are vulnerable periods for increased alcohol and nicotine use. The dramatic increase in the prevalence of electronic cigarette use is particularly concerning in these age groups. Late adolescents and young adults are more likely to engage in cycles of binge drug consumption, and alcohol and nicotine are frequently used together. However, there are few data examining the combination of alcohol and nicotine in binge models in animal models. In this study, our objectives were to determine how voluntary nicotine consumption beginning in late adolescence influenced subsequent binge alcohol consumption in young adulthood, how a combination of alcohol and nicotine binge consumption differed from alcohol-only binge consumption, and whether nicotine would be consumed when presented in a binge procedure. Male C57BL/6J mice voluntarily consumed unsweetened alcohol and nicotine in continuous-access bottle-choice procedures in combination with cycles of drinking-in-the-dark. Our results show that experience with voluntary nicotine consumption in late adolescence did not affect subsequent binge alcohol consumption in early adulthood. However, mice that consumed nicotine in adolescence showed an initial decrease in alcohol preference, and consequently increase in nicotine preference, on the first session of combined ethanol and nicotine binge consumption in adulthood compared with mice that drank only water during late adolescence. Lastly, we found that mice readily consumed unsweetened nicotine when presented in a binge procedure, and the level of consumption exceeded the nicotine consumption observed in the combination alcohol and nicotine binge. Our data show that expansion of the patterns of alcohol and nicotine co-consumption in a mouse models is possible, which will enable us to dissect relevant molecular targets underlying these consumption patterns and better inform drug development efforts.

中文翻译:

酒精和尼古丁摄入的差异模式:小鼠酒精和尼古丁暴饮暴食行为的结合。

与高中和大学时期相对应的青春期后期和青年期是酒精和尼古丁使用增加的脆弱时期。在这些年龄组中,电子烟使用率的急剧增加尤其令人担忧。晚期青少年和年轻人更有可能陷入酗酒的循环,酒精和尼古丁经常一起使用。然而,很少有数据在动物模型的狂欢模型中检查酒精和尼古丁的组合。在这项研究中,我们的目标是确定从青春期晚期开始的自愿尼古丁消费如何影响随后的成年青年酗酒,酒精和尼古丁的狂饮组合与仅酒精的狂饮有何不同,以及在暴饮暴食过程中是否会消耗尼古丁。雄性 C57BL/6J 小鼠在连续进入的瓶子选择程序中自愿消耗不加糖的酒精和尼古丁,并结合在黑暗中饮酒的循环。我们的研究结果表明,在青春期后期自愿消费尼古丁的经验不会影响随后的成年早期酗酒。然而,与青春期后期仅喝水的小鼠相比,在青春期消耗尼古丁的小鼠在成年期首次摄入酒精和尼古丁暴饮暴食时表现出酒精偏好的初始下降,并因此增加了尼古丁偏好。最后,我们发现小鼠在狂欢过程中很容易摄入不加糖的尼古丁,并且消费水平超过了在酒精和尼古丁暴饮暴食中观察到的尼古丁消耗量。我们的数据表明,在小鼠模型中扩大酒精和尼古丁共同消费的模式是可能的,这将使我们能够剖析这些消费模式背后的相关分子靶标,并更好地为药物开发工作提供信息。
更新日期:2020-04-20
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