Diabetes affects more than 425 million people worldwide, a scale approaching pandemic proportion. Diabetes represents a major risk factor for stroke, and therefore is actively addressed for stroke prevention. However, how diabetes affects stroke severity has not yet been extensively considered, which is surprising given the evident but understudied common mechanistic features of both pathologies. The increase in number of diabetic people, incidence of stroke in the presence of this specific risk factor, and the exacerbation of ischemic brain damage in diabetic conditions (at least in animal models) warrants the need to integrate this comorbidity in preclinical studies of brain ischemia to develop novel therapeutic approaches. Therefore, a better understanding of the commonalties involved in the course of both diseases would offer the promise of discovering novel neuroprotective pathways that would be more appropriated to clinical scenarios. In this article, we will review the relevant mechanisms that have been identified as common traits of both pathologies and that could be, to our knowledge, potential targets in both pathologies.

中文翻译：

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缩小糖尿病和中风之间的差距，以寻求高临床相关性治疗目标。

糖尿病在全球影响了超过4.25亿人，这一比例接近大流行的比例。糖尿病是中风的主要危险因素，因此积极预防中风。然而，尚未广泛考虑糖尿病如何影响中风的严重性，鉴于两种病理的明显但未被研究的共同机制特征，这令人惊讶。糖尿病患者人数的增加，在存在这种特定危险因素的情况下中风的发生率以及在糖尿病条件下（至少在动物模型中）缺血性脑损伤的加重需要在脑缺血的临床前研究中整合这种合并症开发新颖的治疗方法。因此，更好地了解这两种疾病的共同点将为发现新的神经保护途径提供希望，该途径将更适合于临床情况。在本文中，我们将回顾相关机制，这些机制已被确定为两种病理的共同特征，就我们所知，这可能是两种病理的潜在靶标。