PURPOSE Low skeletal muscle mass has been associated with poor prognosis in patients with advanced lung cancer. However, little is known about the relationship between skeletal muscle mass and overall survival in patients with bone metastases from lung cancer. The objective of the present study was to evaluate the prognostic value of low trunk muscle mass in predicting overall survival in these patients. METHODS The data from 198 patients who were diagnosed with bone metastases from lung cancer from April 2009 to May 2017 were retrospectively reviewed. The areas of the psoas and paravertebral muscles were measured at the level of the third lumbar vertebra on computed tomography scans taken at the time nearest to the diagnosis of bone metastasis. Muscle area was evaluated for male and female cohorts separately using different cutoff points. Cox proportional hazards analysis was performed to evaluate the factors independently associated with overall survival. RESULTS The overall survival of patients in the lowest quartile for psoas muscle area or paravertebral muscle area was significantly shorter than that of patients above the 25th percentile for muscle area (p < 0.001). Multivariate analyses showed that paravertebral muscle mass (hazard ratio, 1.73; 95% confidence interval, 1.17-2.56; p = 0.006), epidermal growth factor receptor-targeted therapy, and performance status were independent prognostic factors. CONCLUSIONS Low paravertebral muscle mass was associated with shorter survival, independently of known prognostic factors.

中文翻译：

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肺癌骨转移患者的低椎旁肌肉质量与预后不良有关。

目的 低骨骼肌质量与晚期肺癌患者预后不良有关。然而，对于肺癌骨转移患者的骨骼肌质量与总生存率之间的关系知之甚少。本研究的目的是评估低躯干肌肉质量在预测这些患者的总体生存率方面的预后价值。方法回顾性分析2009年4月至2017年5月诊断为肺癌骨转移的198例患者资料。在最接近骨转移诊断的时间进行计算机断层扫描，在第三腰椎水平测量腰大肌和椎旁肌肉的面积。使用不同的截止点分别评估男性和女性队列的肌肉面积。进行 Cox 比例风险分析以评估与总生存期独立相关的因素。结果 腰大肌区域或椎旁肌区域最低四分位数患者的总生存期显着短于肌肉面积超过 25% 的患者（p < 0.001）。多变量分析显示椎旁肌肉质量（风险比，1.73；95% 置信区间，1.17-2.56；p = 0.006）、表皮生长因子受体靶向治疗和体能状态是独立的预后因素。结论 低椎旁肌肉质量与较短的生存期相关，与已知的预后因素无关。结果 腰大肌区域或椎旁肌区域最低四分位数患者的总生存期显着短于肌肉面积超过 25% 的患者（p < 0.001）。多变量分析显示椎旁肌肉质量（风险比，1.73；95% 置信区间，1.17-2.56；p = 0.006）、表皮生长因子受体靶向治疗和体能状态是独立的预后因素。结论 低椎旁肌肉质量与较短的生存期相关，与已知的预后因素无关。结果 腰大肌区域或椎旁肌区域最低四分位数患者的总生存期显着短于肌肉面积超过 25% 的患者（p < 0.001）。多变量分析显示椎旁肌肉质量（风险比，1.73；95% 置信区间，1.17-2.56；p = 0.006）、表皮生长因子受体靶向治疗和体能状态是独立的预后因素。结论 低椎旁肌肉质量与较短的生存期相关，与已知的预后因素无关。95% 置信区间，1.17-2.56；p = 0.006）、表皮生长因子受体靶向治疗和体能状态是独立的预后因素。结论 低椎旁肌肉质量与较短的生存期相关，与已知的预后因素无关。95% 置信区间，1.17-2.56；p = 0.006）、表皮生长因子受体靶向治疗和体能状态是独立的预后因素。结论 低椎旁肌肉质量与较短的生存期相关，与已知的预后因素无关。