Dimethyl fumarate (DMF) treatment in multiple sclerosis (MS) increased the proportion of immunoregulatory CD56bright NK cells and this change was proportional to reductions in CD8+ memory T cells. DMF and monomethyl fumarate (MMF) treatment in vitro had directs effects on NK cells and promoted degranulation and cytotoxicity.

中文翻译：

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富马酸二甲酯治疗可改变多发性硬化症中的NK细胞功能。

富马酸二甲酯（DMF）在多发性硬化症（MS）中的治疗增加了免疫调节性CD56亮NK细胞的比例，这种变化与CD8 +记忆T细胞的减少成比例。DMF和富马酸单甲酯（MMF）的体外处理对NK细胞具有直接的作用，并促进了脱粒和细胞毒性。