Abstract A history of long-term co-divergence means that foamy viruses (family Retroviridae) provide an ideal framework to understanding virus-host evolution over extended time periods. Endogenous foamy viruses (EndFVs) are rare, and to date have only been described in a limited number of mammals, amphibians, reptiles and fish genomes. By screening 414 avian genomes we identified EndFVs in two bird species: the Maguari Stork (Ciconia maguari) and the Oriental Stork (Ciconia boyciana). Analyses of phylogenetic relationships, genome structures and flanking sequences revealed a single origin of EndFVs in Ciconia species. In addition, the marked incongruence between the virus and host phylogenies suggested that this integration event occurred independently in birds. In sum, by providing evidence that birds can be infected with foamy viruses, we fill the last major gap in the taxonomic distribution of foamy viruses and their animal hosts.

中文翻译：

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禽内源性泡沫病毒的鉴定与进化

摘要 长期共同发散的历史意味着泡沫病毒（逆转录病毒科）提供了一个理想的框架来理解病毒-宿主在很长一段时间内的进化。内源性泡沫病毒 (EndFV) 很少见，迄今为止仅在数量有限的哺乳动物、两栖动物、爬行动物和鱼类基因组中进行了描述。通过筛选 414 个禽类基因组，我们在两种鸟类中鉴定了 EndFV：Maguari 鹳 (Ciconia maguari) 和东方鹳 (Ciconia boyciana)。系统发育关系、基因组结构和侧翼序列的分析揭示了 Ciconia 物种中 EndFV 的单一起源。此外，病毒和宿主系统发育之间的明显不一致表明这种整合事件在鸟类中独立发生。总之，通过提供证据证明鸟类可以感染泡沫病毒，