Individuals with concurrent tuberculosis (TB) and Type 2 diabetes (DM) have a higher risk of adverse outcomes. To better understand potential immunological differences, we utilized a comprehensive panel to characterize pro-inflammatory and pro-resolving (i.e., mediators involved in the resolution of inflammation) lipid mediators in individuals with TB and TB-DM. A nested cross-sectional study of 40 individuals (20 newly diagnosed DM and 20 without DM) was conducted within a cohort of individuals with active drug-susceptible treatment-naïve pulmonary TB. Lipid mediators were quantified in serum samples through lipid mediator profiling. We conducted correlation-based analysis of these mediators. Overall, the arachidonic acid-derived leukotriene and prostaglandin families were the most abundant pro-inflammatory lipid mediators, while lipoxins and maresins families were the most abundant pro-resolving lipid mediators in individuals with TB and TB-DM. Individuals with TB-DM had increased correlations and connectivity with both pro-inflammatory and pro-resolving lipid mediators compared to those with TB alone. We identified the most abundant lipid mediator metabolomes in circulation among individuals with TB and TB-DM; in addition, our data shows a substantial number of significant correlations between both pro-inflammatory and pro-resolving lipid mediators in individuals with TB-DM, delineating a molecular balance that potentially defines this comorbidity.

中文翻译：

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结核和结核-糖尿病个体的炎症和消脂的脂质介质。

并发结核病（TB）和2型糖尿病（DM）的个体发生不良后果的风险更高。为了更好地理解潜在的免疫学差异，我们使用了一个全面的专家小组来表征结核病和TB-DM患者中促炎症和促分解（即，参与炎症消解的介质）脂质介质的特征。在一组具有有效药物敏感性未治疗过肺结核的个体中，对40名患者（20名新诊断为DM和20名无DM）进行了嵌套横断面研究。通过脂质介体谱分析定量血清样品中的脂质介体。我们对这些介体进行了基于相关性的分析。总体而言，花生四烯酸衍生的白三烯和前列腺素家族是最丰富的促炎脂质介体，而在TB和TB-DM患者中，脂蛋白和maresins家族是最丰富的促分解脂质介体。与仅患有结核病的人相比，患有结核分枝杆菌的个体与促炎性和分解性脂质介体的相关性和连通性增加。我们确定了TB和TB-DM患者中循环中最丰富的脂质介体代谢组。此外，我们的数据显示，TB-DM患者的促炎和促血脂介质之间存在大量显着的相关性，表明了可能定义这种合并症的分子平衡。与仅患有结核病的人相比，患有结核分枝杆菌的个体与促炎和分解血脂介体的相关性和连通性增加。我们确定了TB和TB-DM患者中循环中最丰富的脂质介体代谢组。此外，我们的数据显示，TB-DM患者的促炎和促血脂介质之间存在大量显着的相关性，表明了可能定义这种合并症的分子平衡。与仅患有结核病的人相比，患有结核分枝杆菌的个体与促炎和分解血脂介体的相关性和连通性增加。我们确定了TB和TB-DM患者中循环中最丰富的脂质介体代谢组。此外，我们的数据显示，TB-DM个体中促炎和促血脂介质之间存在大量显着相关性，描绘了可能定义这种合并症的分子平衡。