There is growing evidence that oxysterols are more than simple metabolites in the pathway from cholesterol to bile acids. Recent data has shown oxysterols to be ligands to nuclear receptors and to G protein-coupled receptors, modulators of N-methyl-d-aspartate receptors and regulators of cholesterol biosynthesis. In this mini-review we will discuss the biosynthetic mechanisms for the formation of different oxysterols and the implication of disruption of these mechanisms in health and disease.

中文翻译：

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氧甾醇作为脂质介质：它们的生物合成基因，酶和代谢产物。

越来越多的证据表明，在从胆固醇到胆汁酸的途径中，氧固醇不仅仅是简单的代谢产物。最新数据显示，氧固醇是核受体和G蛋白偶联受体的配体，N-甲基-d-天冬氨酸受体的调节剂和胆固醇生物合成的调节剂。在这个小型综述中，我们将讨论形成不同氧固醇的生物合成机制，以及这些机制对健康和疾病的破坏作用。