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Functions of medial hypothalamic and mesolimbic dopamine circuitries in aggression.
Current Opinion in Behavioral Sciences ( IF 5 ) Pub Date : 2018-07-03 , DOI: 10.1016/j.cobeha.2018.06.011
Takashi Yamaguchi 1, 2 , Dayu Lin 2, 3, 4
Affiliation  

Aggression is a crucial survival behavior: it is employed to defend territory, compete for food and mating opportunities, protect kin, and resolve disputes. Two highly conserved circuitries emerge as critical substrates for generating and modulating aggression. One circuitry centers on the medial hypothalamus, a brain region essential for driving the expression of aggressive behaviors. The other circuit involves the mesolimbic dopamine cells. Animal studies support essential roles of mesolimbic dopaminergic signaling in assessing the reward value of aggression and reinforcing aggressive behaviors. In this review, we will provide an overview regarding the functions of medial hypothalamus and dopaminergic system in mediating aggressive behaviors and the potential interactions between these two circuitries.



中文翻译:

下丘脑内侧和中脑边缘多巴胺回路在侵袭中的功能。

侵略是一种至关重要的生存行为:它被用来捍卫领土,争夺食物和交配机会,保护亲属和解决争端。出现了两个高度保守的电路,作为产生和调节侵略性的关键基础。一个电路位于下丘脑内侧,这是驱动攻击性行为表达所必需的大脑区域。另一个回路涉及中脑边缘的多巴胺细胞。动物研究支持中脑边缘多巴胺能信号传导在评估攻击性奖励价值和增强攻击行为方面的重要作用。在这篇综述中,我们将提供有关下丘脑内侧和多巴胺能系统在介导攻击行为以及这两个回路之间潜在相互作用中的功能的概述。

更新日期:2018-07-03
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