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Expression of trpv channels during Xenopus laevis embryogenesis.
Gene Expression Patterns ( IF 1.2 ) Pub Date : 2018-10-13 , DOI: 10.1016/j.gep.2018.10.001
Chen Dong 1 , Sudip Paudel 1 , Nana Yaa Amoh 1 , Margaret S Saha 1
Affiliation  

Transient receptor potential (TRP) cation channel genes code for an extensive family of conserved proteins responsible for a variety of physiological processes, including sensory perception, ion homeostasis, and chemical signal transduction. The TRP superfamily consists of seven subgroups, one of which is the transient receptor potential vanilloid (trpv) channel family. While trpv channels are relatively well studied in adult vertebrate organisms given their role in functions such as nociception, thermoregulation, and osmotic regulation in mature tissues and organ systems, relatively little is known regarding their function during embryonic development. Although there are some reports of the expression of specific trpv channels at particular stages in various organisms, there is currently no comprehensive analysis of trpv channels during embryogenesis. Here, performing in situ hybridization, we examined the spatiotemporal expression of trpv channel mRNA during early Xenopus laevis embryogenesis. Trpv channels exhibited unique patterns of embryonic expression at distinct locations including the trigeminal ganglia, spinal cord, cement gland, otic vesicle, optic vesicle, nasal placode, notochord, tailbud, proctodeum, branchial arches, epithelium, somite and the animal pole during early development. We have also observed the colocalization of trpv channels at the animal pole (trpv 2/4), trigeminal ganglia (trpv 1/2), and epithelium (trpv 5/6). These localization patterns suggest that trpv channels may play diverse roles during early embryonic development.



中文翻译:

非洲爪蟾胚胎发生过程中 trpv 通道的表达。

瞬时受体电位 (TRP) 阳离子通道基因编码一个广泛的保守蛋白家族,负责各种生理过程,包括感觉知觉、离子稳态和化学信号转导。TRP 超家族由七个亚群组成,其中之一是瞬时受体电位香草酸 (trpv) 通道家族。虽然考虑到trpv通道在成熟组织和器官系统中伤害感受、温度调节和渗透调节等功能中的作用,trpv通道在成年脊椎动物中得到了相对充分的研究,但对其在胚胎发育过程中的功能知之甚少。尽管有一些关于各种生物体特定阶段特定trpv通道表达的报道,但目前还没有对胚胎发生过程中trpv通道的全面分析。在这里,我们通过原位杂交检测了早期非洲爪蟾胚胎发生过程中trpv通道 mRNA的时空表达。Trpv通道在早期发育过程中在不同位置表现出独特的胚胎表达模式,包括三叉神经节、脊髓、牙骨质、耳泡、视泡、鼻基板、脊索、尾芽、直肠、鳃弓、上皮、体节和动物极。我们还观察到了trpv通道在动物极 ( trpv 2/4)、三叉神经节 ( trpv 1/2) 和上皮细胞 ( trpv 5/6)的共定位。这些定位模式表明trpv通道可能在早期胚胎发育过程中发挥不同的作用。

更新日期:2018-10-13
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