The mitochondrial permeability transition pore (mPTP) has been considered a key contributor to cell death, inducing the process in several major neurodegenerative diseases. To date, the molecular nature of the mPTP remains confounding but its significance is universally acknowledged. Several targets have been screened and inhibition of mPTP has emerged as an attractive field for researchers. Nowadays, in silico-directed studies help to explore new small molecules targeting the mPTP to improve their drug-like properties and bioactivity. Here, we briefly summarize the role of mPTP in neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson disease (PD), and Huntington's disease (HD), and discusses current and future potential therapeutic targets.

中文翻译：

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线粒体通透性过渡孔：神经变性的潜在药物靶标。

线粒体通透性转换孔（mPTP）被认为是导致细胞死亡的关键因素，在几种主要的神经退行性疾病中诱发该过程。迄今为止，mPTP的分子性质仍然令人困惑，但其重要性已得到普遍认可。已经筛选了几个靶标，并且对mPTP的抑制已成为研究人员的一个有吸引力的领域。如今，计算机技术指导的研究有助于探索靶向mPTP的新小分子，以改善其类似药物的特性和生物活性。在这里，我们简要总结了mPTP在神经退行性疾病中的作用，包括阿尔茨海默氏病（AD），帕金森氏病（PD）和亨廷顿氏病（HD），并讨论了当前和将来的潜在治疗靶点。