Infectious diseases are a major challenge for the poultry industry that causes widespread production losses. Thus, management and control of poultry health and diseases are essential for the viability of the industry. Toll-like receptors are best characterized as membrane-bound receptors that perform a central role in immune homeostasis and disease resistance by recognition of pathogen-associated molecular patterns. In response to pathogen recognition, TLRs initiate both innate and adaptive immune responses which may help to develop immunomodulatory therapeutics for TLR associated diseases. Vaccination produces specific immunity in the animal’s body towards pathogens. However, due to certain disadvantages of vaccines, (inactivation of attenuated pathogens into the virulent strains and weak immunogenicity of inactivated vaccines) there is a crucial need to develop the safe and effective therapeutic intervention. TLR ligands have been classified as a potential adjuvant against the infectious diseases in farm animals. TLR adjuvants induce both specific and nonspecific immune responses in chickens to combat several bacterial, viral and parasitic diseases. Therefore, the aim of this review was to explore the chicken TLR4 and their role in immune responses and disease resistance to develop disease resistance poultry breeds in future.

传染病是造成广泛生产损失的家禽业的主要挑战。因此，对家禽健康和疾病的管理和控制对于该行业的生存至关重要。Toll样受体最能表征为膜结合受体，通过识别病原体相关分子模式在免疫稳态和疾病抵抗中发挥重要作用。作为对病原体识别的响应，TLR启动固有的和适应性的免疫反应，这可能有助于开发针对TLR相关疾病的免疫调节疗法。疫苗接种会在动物体内产生针对病原体的特定免疫力。但是，由于疫苗的某些缺点，（将减毒病原体灭活为强毒株和灭活疫苗的弱免疫原性）迫切需要开发安全有效的治疗干预措施。TLR配体已被分类为抗牲畜传染病的潜在佐剂。TLR佐剂可在鸡中诱导特异性和非特异性免疫反应，以抵抗多种细菌，病毒和寄生虫病。因此，本综述的目的是探讨鸡TLR4及其在免疫应答和抗病性中的作用，以在将来开发抗病家禽品种。TLR佐剂可在鸡中诱导特异性和非特异性免疫反应，以抵抗多种细菌，病毒和寄生虫病。因此，本综述的目的是探讨鸡TLR4及其在免疫应答和抗病性中的作用，以在将来开发抗病家禽品种。TLR佐剂可在鸡中诱导特异性和非特异性免疫反应，以抵抗多种细菌，病毒和寄生虫病。因此，本综述的目的是探讨鸡TLR4及其在免疫应答和抗病性中的作用，以在将来开发抗病家禽品种。