Adipose tissue has been considered as a crucial source of certain pro-inflammatory cytokines; conversely, these pro-inflammatory cytokines are involved in regulating the proliferation and apoptosis of adipocytes, promoting lipolysis, inhibiting lipid synthesis and decreasing blood lipids, etc. In recent decades, extensive studies have indicated that pro-inflammatory cytokines play important roles in the development of lipid metabolism of metabolic diseases, including obesity, atherosclerosis, steatohepatitis and hyperlipoproteinemia. However, the involved pro-inflammatory cytokines types and the underlying mechanisms remain largely unknown. The “re-discovery” of cancer as a metabolic disorder largely occurred in the last five years. Although pro-inflammatory cytokines have been intensively investigated in cancer research, there are very few studies about the roles of pro-inflammatory cytokines in the lipid metabolism of cancer. In the current review, we provide an overview of the progress that has been made in the roles of different pro-inflammatory cytokines in lipid metabolism of metabolic diseases including cancer.

脂肪组织被认为是某些促炎细胞因子的重要来源。相反，这些促炎细胞因子参与调节脂肪细胞的增殖和凋亡，促进脂肪分解，抑制脂质合成和降低血脂等。最近几十年，广泛的研究表明促炎细胞因子在发育中起着重要作用。代谢疾病的脂质代谢，包括肥胖，动脉粥样硬化，脂肪性肝炎和高脂蛋白血症。然而，所涉及的促炎性细胞因子类型和潜在机制仍然很大程度上未知。在过去的五年中，癌症作为代谢紊乱的“重新发现”在很大程度上发生了。尽管促炎细胞因子已在癌症研究中进行了深入研究，关于促炎细胞因子在癌症脂质代谢中的作用的研究很少。在当前的审查中，我们概述了不同促炎细胞因子在包括癌症在内的代谢性疾病的脂质代谢中所起的作用。