In the last 5 years, a wide variety of surface modification strategies are explored to improve the integration of poly(etheretherketone) (PEEK) implants with bone. Since PEEK does not support bone on‐growth, its surface properties need to be tailored to promote osteogenesis at the bone‐implant interface. Surface modifications applied to achieve this response range from simple surface morphology changes to the deposition of osteoconductive coatings. Of the many methods, titanium and/or hydroxyapatite coatings, extrusion to create surface pores, and an accelerated neutral atom beam treatment have been approved by the U.S. Food and Drug Administration to improve the integration of PEEK spinal cages. The success of these surface modifications brings hope for the clinical translation of other techniques in the future, but there are several limitations that may be preventing other treatments from reaching the clinic. This review describes numerous strategies that have been applied to PEEK‐based implants for improving their osseointegration and enhancing their antibacterial properties. The review concludes with a discussion about future directions for the field and provides suggestions for advancing clinical translation of surface‐modified PEEK implants to improve the lives of patients in need of these implants.

中文翻译：

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改善聚醚醚酮及其复合材料骨整合的表面改性策略。

在最近的5年中，人们探索了多种表面修饰策略，以改善聚醚醚酮（PEEK）植入物与骨骼的融合。由于PEEK不支持骨骼生长，因此需要调整其表面性质以促进在骨植入界面处的成骨作用。为实现该响应而进行的表面改性包括从简单的表面形态变化到骨传导涂层的沉积。在许多方法中，钛和/或羟基磷灰石涂层，挤出以产生表面孔以及加速的中性原子束处理已获得美国食品和药物管理局的批准，以改善PEEK脊柱保持架的整体性。这些表面修饰的成功为将来其他技术的临床翻译带来了希望，但是存在一些局限性，可能会阻止其他疗法进入临床。这篇综述描述了许多已应用于基于PEEK的植入物的策略，以改善其骨整合和增强其抗菌性能。该评论最后讨论了该领域的未来发展方向，并为推进表面改性PEEK植入物的临床翻译以改善需要这些植入物的患者的生活提供了建议。