Background: Systemic lupus erythematosus (SLE) is associated with a constellation of complications affecting multiple organs, including neuropsychiatric manifestations (NPSLE) and ischaemic events, leading to increased long-term morbidity. Antiphospholipid antibodies (aPL) are a major determinant of vascular inflammation and thromboembolic risk. The diagnostic role of anti-phosphatidylserine/prothrombin (aPS/PT) antibodies in this setting is incompletely defined.Aim: To verify whether aPS/PT add to diagnostics and disease stratification in patients with SLE with or without other aPL.Methods: 131 consecutive patients were studied, including 20 patients with SLE and secondary antiphospholipid syndrome (APS). aPS/PT IgG and IgM were assessed through ELISA and patients were stratified based on the presence of other aPL, on their clinical and laboratory features at time of blood sampling and on their clinical history. Synthetic indices of disease activity, chronic damage and cardiovascular risk were calculated at time of venipuncture.Results: Fifty-one (38.9%) patients with SLE had aPS/PT and 15 (11.5%) patients had aPS/PT as the only aPL (aPS/PT-only). aPS/PT-only patients had a significantly higher prevalence of NPSLE than quadruple aPL-negative patients (p = .007). Patients with aPS/PT were more likely to have a history of ischaemia, thrombocytopenia and Libman-Sacks' endocarditis. The presence of aPS/PT also associated with previous accrual of at least one damage item (p = .043), but had limited predictive values for damage progression in the short term.Conclusion: aPS/PT antibodies provide non-redundant information that could contribute to risk assessment and stratification of patients with SLE.

中文翻译：

---

aPS / PT抗体对神经性红斑狼疮和系统性红斑狼疮的心血管并发症的诊断性能。

背景：系统性红斑狼疮（SLE）与一系列影响多个器官的并发症有关，包括神经精神病学表现（NPSLE）和缺血性事件，从而导致长期发病率增加。抗磷脂抗体（aPL）是血管炎症和血栓栓塞风险的主要决定因素。抗磷脂酰丝氨酸/凝血酶原（aPS / PT）抗体在这种情况下的诊断作用尚未完全确定。目的：验证aPS / PT是否可增加SLE患者是否伴有其他aPL的诊断和疾病分层方法：连续131次对包括20例SLE和继发性抗磷脂综合征（APS）的患者进行了研究。通过ELISA对aPS / PT IgG和IgM进行​​评估，并根据是否存在其他aPL对患者进行分层，在采血时的临床和实验室特征及其临床病史。静脉穿刺时计算疾病活动度，慢性损伤和心血管风险的综合指标。结果：52例SLE患者中aPS / PT是aPS / PT，15例11.11％患者是aPS / PT作为唯一aPL（仅适用于aPS / PT）。仅aPS / PT患者比四联aPL阴性患者的NPSLE患病率明显更高（p = .007）。患有aPS / PT的患者更容易出现局部缺血，血小板减少和Libman-Sacks心内膜炎的病史。aPS / PT的存在还与先前至少应计一个损伤项目有关（p = .043），但短期内对损伤进展的预测价值有限。