Pregnancy, N-Methyl-D-Aspartate Receptor Antibodies, andNeuropsychiatric Diseases Josep Dalmau, MD, PhD Jurek and colleagues used a recombinant monoclonal antibody (ab) derived from a patient with anti–N-methyl-D-aspartate receptor encephalitis (anti-NMDARe) to show that systemic administration to pregnant mice resulted in 27% postnatal mortality, altered levels of NMDARs, impaired neurodevelopmental reflexes, and had long-lasting neuropathological effects. Searching for a human application for these findings, the authors determined the presence of NMDAR abs in serum of asymptomatic mothers of patients with neuropsychiatric disorders (MPs) and mothers of healthy persons (MCs) serving as controls. None of the mothers had a history of anti-NMDARe, and their serum was tested 4 to 20 years after pregnancy. The authors found a spectrum of NMDAR-abs slightly higher in MPs than in MCs, concluding that low-level NMDAR-abs of asymptomatic MPs can be transferred to the fetus, causing neuropsychiatric morbidity. Considering the experience with humans, these conclusions are premature and can be distressing for patients with a history of anti-NMDARe who remain ab-positive for a long time after

中文翻译：

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妊娠、NMDA 受体抗体和神经精神疾病

妊娠、N-甲基-D-天冬氨酸受体抗体和神经精神疾病 Josep Dalmau, MD, PhD Jurek 及其同事使用了一种重组单克隆抗体 (ab)，该抗体来自一名患有抗 N-甲基-D-天冬氨酸受体脑炎（抗- NMDARe) 表明，对怀孕小鼠进行全身给药会导致 27% 的出生后死亡率、NMDAR 水平改变、神经发育反射受损，并具有持久的神经病理学影响。为了寻找这些发现的人类应用，作者确定了神经精神疾病 (MP) 患者的无症状母亲和作为对照的健康人 (MC) 母亲的血清中存在 NMDAR abs。所有母亲都没有抗 NMDARe 的病史，并且在怀孕 4 至 20 年后检测了她们的血清。作者发现 MP 中的 NMDAR-abs 谱略高于 MC，结论是无症状 MP 的低水平 NMDAR-abs 可以转移到胎儿，导致神经精神疾病。考虑到人类的经验，这些结论还为时过早，对于有抗 NMDARe 病史的患者来说可能会感到痛苦，这些患者在之后很长一段时间内仍保持 ab 阳性