Chloroquines are 4-aminoquinoline-based drugs mainly used to treat malaria. At pharmacological concentrations, they have significant effects on tissue homeostasis, targeting diverse signaling pathways in mammalian cells. A key target pathway is autophagy, which regulates macromolecule turnover in the cell. In addition to affecting cellular metabolism and bioenergetic flow equilibrium, autophagy plays a pivotal role at the interface between inflammation and cancer progression. Chloroquines consequently have critical effects in tissue metabolic activity and importantly, in key functions of the immune system. In this article, we will review the work addressing the role of chloroquines in the homeostasis of mammalian tissue, and the potential strengths and weaknesses concerning their use in cancer therapy.

中文翻译：

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剖析氯喹在癌症治疗中的药理作用：干扰炎症信号通路。

氯喹是 4-氨基喹啉类药物，主要用于治疗疟疾。在药理学浓度下，它们对组织稳态有显着影响，针对哺乳动物细胞中的多种信号通路。一个关键的目标途径是自噬，它调节细胞中的大分子周转。除了影响细胞代谢和生物能流动平衡之外，自噬在炎症和癌症进展之间的界面中发挥着关键作用。因此，氯喹对组织代谢活动具有重要影响，更重要的是，对免疫系统的关键功能具有重要影响。在本文中，我们将回顾有关氯喹在哺乳动物组织稳态中的作用的工作，以及它们在癌症治疗中使用的潜在优点和缺点。