PURPOSE To estimate how many boys with UDT must undergo orchiopexy to prevent one case of TC, one death from TC and one exposure to TC treatment beyond radical orchiectomy as compared to being treated at an older age. METHODS This retrospective study utilized data from a 2007 Swedish study of males who underwent orchiopexy for UDT (Pettersson et al.). TC incidence for boys undergoing orchiopexy for UDT was assessed based on the age at orchiopexy (0-6 years, 7-9 years, 10-12 years, 13-15 years). The incidence of TC in each age cohort was calculated and used to determine the number needed to treat (NNT) for each age group using assumptions based on published TC outcomes. RESULTS For an index patient ≤ 6 years, 372 boys need to undergo orchiopexy to prevent a single case of TC, 1488 boys to prevent exposure to TC therapy beyond radical orchiectomy, and 5315 boys to prevent a single TC-related death compared to treatment at an older age. CONCLUSION While there is evidence supporting benefits of early orchiopexy, the NNT to affect TC outcomes is very high. Even those with delayed orchiopexies have low risk for TC poor outcomes. This information can be used when counseling patients and families faced with UDT about the risks related to TC, especially with comorbidities.

中文翻译：

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视神经支配年龄对睾丸癌预后的影响。

目的估计与年龄较大的男孩相比，有多少UDT男孩必须接受睾丸矫正术以预防一例TC，一例TC死亡，一例接受根治性睾丸切除术以外的TC治疗。方法这项回顾性研究利用了2007年瑞典一项针对UDT进行了睾丸手术的男性进行的研究（Pettersson等人）的数据。根据睾丸固定年龄（0-6岁，7-9岁，10-12岁，13-15岁）评估接受UDT进行睾丸固定的男孩的TC发生率。计算每个年龄组中TC的发生率，并使用基于已公布的TC结果的假设，将其用于确定每个年龄组的需要治疗的人数（NNT）。结果对于≤6岁的指数患者，需要对372名男孩进行睾丸检查以预防一例TC，而对于1488名男孩要进行彻底的睾丸切除术以防止接受TC治疗，和5315个男孩相比，与较大年龄的治疗相比，它可以预防与TC相关的死亡。结论尽管有证据支持早期睾丸手术的益处，但影响TC结果的NNT很高。甚至那些睾丸延迟症患者，TC不良结局的风险也较低。当向面对UDT的患者和家属咨询与TC相关的风险（尤其是合并症）时，可以使用此信息。