Systemic lupus erythematosus is a systemic autoimmune inflammatory disease with a broad spectrum of clinical presentations. Mouse models play an indispensible role in understanding the disease pathology and for developing new therapeutics. This study investigated the effect of pristane administration on female BALB/c mice. The various manifestations of lupus replicated in this mouse model were analysed and their relevance to human disease was assessed. Pristane injection replicates the two prime manifestations of lupus i.e. oxidative stress and inflammation. An increase in oxidative stress was determined by the decreasing anti-oxidants, increasing ROS and lipid peroxidation. Inflammatory cytokines (IL-6 and TNF-α) also increased in the plasma. The deteriorating organ functions after pristane administration were evident histopathologically. An increase in inflammatory cells, necrosis, oil vacuoles and pigment cells were marked in kidney, liver, lungs and spleen, whereas skin did not manifest any alteration. Liver function (bilirubin, SGPT) and kidney function (creatinine and proteinuria) tests were also altered. Pristane injection caused the generation of anti-nuclear antibodies, which were apparent from the different immunofluorescence patterns observed. Immune deposits were evident in all the vital organs stating the similarity this model holds with lupus patients. Replicating various manifestations of human lupus disorder, pristane induced mouse model of lupus serves as an appropriate model to study lupus complications and in the development of novel therapeutics for disease management.

中文翻译：

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氧化应激和免疫复合物：p烷诱导的狼疮鼠模型的致病机制。

系统性红斑狼疮是一种系统性自身免疫性炎性疾病，具有广泛的临床表现。小鼠模型在理解疾病病理和开发新疗法中起着不可或缺的作用。这项研究调查了rist烷对雌性BALB / c小鼠的影响。分析了在该小鼠模型中复制的狼疮的各种表现，并评估了它们与人类疾病的相关性。rist烷注射复制了狼疮的两个主要表现，即氧化应激和炎症。通过减少抗氧化剂，增加ROS和脂质过氧化来确定氧化应激的增加。血浆中的炎性细胞因子（IL-6和TNF-α）也增加。注射rist烷后器官的功能恶化在组织病理学上是明显的。肾，肝，肺和脾脏中炎症细胞，坏死，油泡和色素细胞的增加明显，而皮肤没有任何变化。肝功能（胆红素，SGPT）和肾功能（肌酐和蛋白尿）的检测也发生了改变。rist烷注射引起抗核抗体的产生，从观察到的不同免疫荧光模式可以明显看出。在所有重要器官中都有明显的免疫沉淀，表明该模型与狼疮患者相似。rist烷诱导的狼疮小鼠模型可复制人类狼疮疾病的各种表现形式，是研究狼疮并发症和开发新型疾病治疗方法的合适模型。肝，肺和脾脏，而皮肤没有任何变化。肝功能（胆红素，SGPT）和肾功能（肌酐和蛋白尿）的检测也发生了改变。rist烷注射引起抗核抗体的产生，从观察到的不同免疫荧光模式可以明显看出。在所有重要器官中都有明显的免疫沉淀，表明该模型与狼疮患者相似。rist烷诱导的狼疮小鼠模型可复制人类狼疮疾病的各种表现形式，是研究狼疮并发症和开发新型疾病治疗方法的合适模型。肝，肺和脾脏，而皮肤没有任何变化。肝功能（胆红素，SGPT）和肾功能（肌酐和蛋白尿）的检测也发生了改变。rist烷注射引起抗核抗体的产生，从观察到的不同免疫荧光模式可以明显看出。在所有重要器官中都有明显的免疫沉淀，表明该模型与狼疮患者相似。rist烷诱导的狼疮小鼠模型可复制人类狼疮疾病的各种表现形式，是研究狼疮并发症和开发新型疾病治疗方法的合适模型。rist烷注射引起抗核抗体的产生，从观察到的不同免疫荧光模式可以明显看出。在所有重要器官中都有明显的免疫沉淀，表明该模型与狼疮患者相似。rist烷诱导的狼疮小鼠模型复制了人类狼疮疾病的各种表现形式，是研究狼疮并发症和开发疾病治疗新疗法的合适模型。rist烷注射引起抗核抗体的产生，从观察到的不同免疫荧光模式可以明显看出。在所有重要器官中都有明显的免疫沉淀，表明该模型与狼疮患者相似。rist烷诱导的狼疮小鼠模型复制了人类狼疮疾病的各种表现形式，是研究狼疮并发症和开发疾病治疗新疗法的合适模型。