Abstract

A mass spectrometric method has been developed for determining the content of dopamine and serotonin derivatives, which allows evaluating the efficiency of their penetration through artificial membranes depending on the structure of their peptide fragment. In this case, the diffusion of dopamine and serotonin derivatives through the membrane occurred as a result of competitive interactions. It was shown which compounds in this mixture more easily penetrate through artificial membranes. It was found that the most promising in terms of overcoming the BBB are Boc–Pro–Srt and Boc–Pro–DOPA.

中文翻译：

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通过人造膜渗透多巴胺和5-羟色胺肽衍生物的效率。

摘要

已经开发出一种用于测定多巴胺和5-羟色胺衍生物的含量的质谱方法，该方法允许根据它们的肽片段的结构来评估它们穿透人造膜的效率。在这种情况下，由于竞争性相互作用，发生了多巴胺和5-羟色胺衍生物通过膜的扩散。结果表明，该混合物中的哪些化合物更容易穿透人造膜。发现在克服BBB方面最有希望的是Boc–Pro–Srt和Boc–Pro–DOPA。