Abstract

It was shown previously that cycloprolylglycine, an endogenous neuropeptide, is a positive AMPA receptor modulator and is able to increase the content of BDNF in neurons. In the present study, using the model of learned helplessness in rats, we showed that cycloprolylglycine at a dose of 1 mg/kg at subchronic intraperitoneal administration reduced the time of animal immobility to passive control values (from 167.6 to 83.6 s) on day 12 of the experiment. This indicates the presence of antidepressant-like activity. The results of the study allow us to consider cycloprolylglycine as a component in the physiological regulation of the depression-like state.

中文翻译：

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内源性抑郁样状态调节机制的新组成部分。

摘要

先前已证明，内源性神经肽环脯氨酰甘氨酸是AMPA受体的正调节剂，能够增加神经元中BDNF的含量。在本研究中，使用大鼠的学习性无助模型，我们显示在亚慢性腹膜内给药时1 mg / kg剂量的环脯氨酰甘氨酸可将动物固定时间在第12天降至被动控制值（从167.6到83.6 s）实验的 这表明存在抗抑郁样活性。研究结果使我们可以考虑将环脯氨酰甘氨酸作为抑郁样状态的生理调节成分。