Abstract

Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist–tricyclic antidepressant amitriptyline—significantly inhibits store-dependent Ca²⁺ entry, induced by endoplasmic Ca²⁺-ATPase inhibitors thapsigargin and cyclopiazonic acid, in rat peritoneal macrophages. The results suggest a possible involvement of sigma-1 receptors in the regulation of store-dependent Ca²⁺ entry in macrophages.

中文翻译：

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Sigma-1受体激动剂阿米替林抑制巨噬细胞中依赖于存储的Ca2 +进入。

摘要

使用Fura-2AM微荧光法，我们首次证明sigma-1受体激动剂三环抗抑郁剂阿米替林可显着抑制大鼠内源性Ca ²⁺ -ATPase抑制剂thapsigargin和环吡嗪酸诱导的依赖于存储的Ca ²⁺进入。腹腔巨噬细胞。结果表明，sigma-1受体可能参与巨噬细胞中依赖于存储的Ca ²⁺进入的调节。