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Anti-Inflammatory Effect of Exercise Mediated by Toll-Like Receptor Regulation in Innate Immune Cells - A Review.
International Reviews of Immunology ( IF 5 ) Pub Date : 2019-11-04 , DOI: 10.1080/08830185.2019.1682569
Nicolas Collao 1 , Isabel Rada 1 , Marc Francaux 2 , Louise Deldicque 2 , Hermann Zbinden-Foncea 1, 3
Affiliation  

Over the last three decades, the combination of a sedentary lifestyle and excessive food intake has led to a significant increase in the prevalence of obesity. The latter favors a chronic low-grade inflammatory state and an over-activation of the innate immune system, which contribute to insulin resistance and type 2 diabetes. Physical exercise is a powerful preventive tool and treatment for several diseases as it induces metabolic and immune effects that provide health benefits. Exercise is known to reduce inflammation; however, the underlying mechanisms responsible are not fully elucidated. One proposed mechanism is a reduced expression and/or activation of pro-inflammatory toll-like receptors (TLRs) on innate immune cells after exercise, which could contribute to the protective effect of exercise against insulin resistance and the prevention of the development of metabolic diseases. The aim of the present study is therefore to review the current evidence about the anti-inflammatory effects of exercise and toll-like receptors regulation on immune cells in humans.Key PointsObesity leads to a low-grade chronic inflammatory state and an over-activation of the innate immune system that is directly involved in the develop metabolic syndrome.The anti-inflammatory effect of exercise has been previously suggested through the reduction of the expression and/or activation of pro-inflammatory toll-like receptors (TLRs) in innate immune cells, which represent one of the main inflammatory responses triggered by obesityThe underlying mechanisms in which toll-like receptors expression modulate the reduction of chronic inflammation are not fully elucidated.

中文翻译:

类似的Toll样受体调节介导的运动对先天免疫细胞的抗炎作用-综述。

在过去的三十年中,久坐不动的生活方式和过多的食物摄入导致肥胖的发生率显着增加。后者有利于慢性低度炎症状态和先天免疫系统过度激活,这会导致胰岛素抵抗和2型糖尿病。体育锻炼是多种疾病的有力预防工具,可诱导新陈代谢和免疫作用,对健康有益。众所周知,运动可以减少炎症。但是,尚未完全阐明负责任的潜在机制。一种提议的机制是运动后先天免疫细胞上促炎性Toll样受体(TLR)的表达减少和/或激活,这可能有助于运动对抗胰岛素抵抗的保护作用,并预防代谢性疾病的发展。因此,本研究的目的是综述有关运动和通行费样受体调节对人体免疫细胞的抗炎作用的最新证据。要点肥胖症会导致低度的慢性炎性状态和过度激活运动的抗炎作用先前已通过减少先天免疫细胞中促炎性通行费样受体(TLR)的表达和/或激活而被提出,具有抗炎作用。 ,
更新日期:2020-04-20
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