Pregnancy, a challenging physiological state, requires shuffling of conventional immune work-sets. Strategies to tolerate the semi-allogenic fetus in normal human pregnancy are multivariate with perfect modulation of the immune cells. Pregnancy is marked by B cell lymphocytopenia accompanied by reduced responsiveness to infectious agents. Besides this old age concept, plenty of research confirms that B cells have other crucial roles in pregnancy and undergo a wide range of modifications in terms of its proliferation, switching between its subtypes, variation in antibody productions, shifting the tides of cytokines as well as regulating other immune cells. B cells establish tolerant environment in pregnancy by producing protective antibodies to encounter the foreign paternal antigens. Regulatory B cells (Bregs) have adopted anti-inflammatory characteristics to sustain normal pregnancy. Moreover, the colossal physiological alterations during human pregnancy also include synchronized changes in the cross-talks between the pregnancy hormones and B cells. These aspects of pregnancy from the view point of B cell functions have so far appeared individually in discrete reports. This review finds its novelty in concisely presenting every facet of association of B cell with human pregnancy.

中文翻译：

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孕妇B细胞的生殖免疫调节功能。

怀孕是一种具有挑战性的生理状态，需要改组常规的免疫工作系统。在正常人的妊娠中，耐受半同种异体胎儿的策略是多种多样的，可以完美地调节免疫细胞。怀孕的特征是B细胞淋巴细胞减少，并伴有对传染原反应的降低。除了这个老年概念外，大量研究证实，B细胞在妊娠中还具有其他重要作用，并且在其增殖，亚型之间切换，抗体产生变化，改变细胞因子的潮汐等方面经历了广泛的修饰。调节其他免疫细胞。B细胞通过产生保护性抗体来遇到外源性父亲抗原，从而在妊娠中建立了耐受环境。调节性B细胞（Bregs）具有抗炎特性，可以维持正常妊娠。此外，人类怀孕期间的巨大生理变化还包括怀孕激素与B细胞之间串扰的同步变化。迄今为止，从B细胞功能的角度来看，怀孕的这些方面分别出现在不同的报告中。这篇评论发现了它在新颖呈现B细胞与人类怀孕相关的各个方面的新颖性。