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The association between sarcopenia and osteoporotic vertebral compression refractures.
Osteoporosis International ( IF 4 ) Pub Date : 2019-09-03 , DOI: 10.1007/s00198-019-05144-x
W-F Wang 1 , C-W Lin 1 , C-N Xie 1 , H-T Liu 1 , M-Y Zhu 1 , K-L Huang 1 , H-L Teng 1
Affiliation  

Sarcopenia was reported to be significantly associated with osteoporosis. In this study, we reported for the first time that sarcopenia was an independent risk predictor of osteoporotic vertebral compression refractures (OVCRFs). Other risk factors of OVCRFs are low bone mass density T-scores, female sex, and advanced age. INTRODUCTION The purpose of this study was to investigate the association between osteoporotic vertebral compression refractures (OVCRFs) and sarcopenia, and to identify other risk factors of OVCRFs. METHODS We evaluated 237 patients with osteoporotic vertebral compression fracture who underwent percutaneous kyphoplasty (PKP) in our hospital from August 2016 to December 2017. To diagnose sarcopenia, a cross-sectional computed tomography (CT) image at the inferior aspect of the third lumbar vertebra (L3) was selected for estimating muscle mass. Grip strength was used to assess muscle strength. Possible risk factors, such as age, sex, body mass index (BMI), bone mineral density (BMD), location of the treated vertebra, anterior-posterior ratio (AP ratio) of the fractured vertebra, cement leakage, and vacuum clefts, were assessed. The multivariable analysis was used to determine the risk factors of OVCRFs. RESULTS During the follow-up period, OVCRFs occurred in 64 (27.0%) patients. Sarcopenia was present in 48 patients (20.3%), including 21 OVCRFs and 27 non-OVCRFs patients. Sarcopenia was significantly correlated with advanced age, lower BMI, lower BMD, and hypoalbuminemia. Compared with non-sarcopenic patients, sarcopenic patients had higher OVCRFs risk. In univariate analysis, sarcopenia (p = 0.003), female (p = 0.024), advanced age (≥ 75 years; p < 0.001), lower BMD (p < 0.001), lower BMI (p = 0.01), TL junction (vertebral levels at the thoracolumbar junction) (p = 0.01), cardiopulmonary comorbidity (p = 0.042), and hypoalbuminemia (p = 0.003) were associated with OVCRFs. Multivariable analysis revealed that sarcopenia (OR 2.271; 95% CI 1.069-4.824, p = 0.033), lower BMD (OR 1.968; 95% CI 1.350-2.868, p < 0.001), advanced age (≥ 75 years; OR 2.431; 95% CI 1.246-4.744, p = 0.009), and female sex (OR 4.666; 95% CI 1.400-15.552, p = 0.012) were independent risk predictors of OVCRFs. CONCLUSIONS Sarcopenia is an independent risk predictor of osteoporotic vertebral compression refractures. Other factors affecting OVCRFs are low BMD T-scores, female sex, and advanced age.

中文翻译:

肌肉减少症与骨质疏松性椎体压缩再骨折之间的关联。

据报道,肌肉减少症与骨质疏松症显着相关。在这项研究中,我们首次报道肌肉减少症是骨质疏松性椎体压缩再骨折 (OVCRFs) 的独立风险预测因子。OVCRFs 的其他风险因素是低骨量密度 T 分数、女性和高龄。引言 本研究的目的是调查骨质疏松性椎体压缩再骨折 (OVCRFs) 与肌肉减少症之间的关系,并确定 OVCRFs 的其他危险因素。方法 我们评估了 2016 年 8 月至 2017 年 12 月在我院接受经皮后凸成形术(PKP)的 237 例骨质疏松性椎体压缩性骨折患者。诊断肌肉减少症,选择第三腰椎 (L3) 下方的横截面计算机断层扫描 (CT) 图像来估计肌肉质量。握力用于评估肌肉力量。可能的危险因素,如年龄、性别、体重指数(BMI)、骨矿物质密度(BMD)、治疗椎体的位置、骨折椎体的前后比(AP比)、骨水泥渗漏和真空裂隙,进行了评估。多变量分析用于确定OVCRFs的危险因素。结果 在随访期间,64 名 (27.0%) 患者发生了 OVCRFs。48 名患者 (20.3%) 出现肌肉减少症,包括 21 名 OVCRFs 和 27 名非 OVCRFs 患者。肌肉减少症与高龄、较低的 BMI、较低的 BMD 和低白蛋白血症显着相关。与非少肌症患者相比,少肌症患者的 OVCRFs 风险较高。在单变量分析中,肌肉减少症 (p = 0.003)、女性 (p = 0.024)、高龄 (≥ 75 岁;p < 0.001)、较低的 BMD (p < 0.001)、较低的 BMI (p = 0.01)、TL 结(椎体胸腰段交界处的水平)(p = 0.01)、心肺合并症(p = 0.042)和低白蛋白血症(p = 0.003)与 OVCRF 相关。多变量分析显示肌肉减少症(OR 2.271;95% CI 1.069-4.824,p = 0.033)、BMD 降低(OR 1.968;95% CI 1.350-2.868,p < 0.001)、高龄(≥ 75 岁;OR 2.431;95 % CI 1.246-4.744,p = 0.009)和女性(OR 4.666;95% CI 1.400-15.552,p = 0.012)是 OVCRF 的独立风险预测因子。结论 肌肉减少症是骨质疏松性椎体压缩再骨折的独立风险预测因子。影响 OVCRFs 的其他因素是低 BMD T 分数,
更新日期:2019-09-03
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