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Quantitative confocal optical coherence elastography for evaluating biomechanics of optic nerve head using Lamb wave model.
Neurophotonics ( IF 5.3 ) Pub Date : 2019-11-15 , DOI: 10.1117/1.nph.6.4.041112
Zhaodong Du 1, 2 , Runze Li 2, 3 , Xuejun Qian 2, 3 , Gengxi Lu 2, 3 , Yan Li 4, 5 , Youmin He 4, 5 , Yueqiao Qu 4, 5 , Laiming Jiang 2 , Zeyu Chen 3 , Mark S Humayun 2 , Zhongping Chen 4, 5 , Qifa Zhou 2, 3
Affiliation  

The mechanosensitivity of the optic nerve head (ONH) plays a pivotal role in the pathogenesis of glaucoma. Characterizing elasticity of the ONH over changing physiological pressure may provide a better understanding of how changes in intraocular pressure (IOP) lead to changes in the mechanical environment of the ONH. Optical coherence elastography (OCE) is an emerging technique that can detect tissue biomechanics noninvasively with both high temporal and spatial resolution compared with conventional ultrasonic elastography. We describe a confocal OCE system in measuring ONH elasticity in vitro, utilizing a pressure inflation setup in which IOP is controlled precisely. We further utilize the Lamb wave model to fit the phase dispersion curve during data postprocessing. We present a reconstruction of Young's modulus of the ONH by combining our OCE system with a Lamb wave model for the first time. This approach enables the quantification of Young's modulus of the ONH, which can be fit using a piecewise polynomial to the corresponding IOP.

中文翻译:

共聚焦光学相干弹性成像技术,使用兰姆波模型评估视神经乳头的生物力学。

视神经乳头(ONH)的机械敏感性在青光眼的发病机理中起关键作用。通过改变生理压力来表征ONH的弹性可以更好地了解眼压(IOP)的变化如何导致ONH的机械环境发生变化。光学相干弹性成像(OCE)是一种新兴技术,与常规超声弹性成像相比,它可以无创地以高时间和空间分辨率无创地检测组织生物力学。我们描述了一种共聚焦OCE系统,该系统使用压力膨胀设置(在其中精确控制IOP)在体外测量ONH弹性。在数据后处理期间,我们进一步利用Lamb波模型拟合相散曲线。我们提出了Young'的重建 通过将我们的OCE系统与Lamb波模型首次结合,获得ONH的模数。这种方法可以量化ONH的杨氏模量,可以使用分段多项式将其拟合到相应的IOP。
更新日期:2019-11-01
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