HCMV coevolved with humans for millions of years and is now one of the most widespread infections worldwide. For a long time HCMV seropositivity was considered a safe clinical condition. In recent decades both clinical observations and research results indicated that the very presence of HCMV in human organism specifically influences immune system and may affect reproduction as a process greatly dependent on immune cells function. Anti-HCMV IgG, IgG avidity, lymphocyte subsets as well as NK cytotoxicity was investigated in 470 infertile women who were eligible for IVF/ET. 419 patients were IgG anti-HCMV-positive (HCMV-seropositive) and only 51 (10.8 %) were IgG anti- HCMV-negative (HCMV-seronegative). There was not a single case of clinically significant level of low-avidity IgG. HCMV-seropositive patients had significantly increased levels of HLA-DR expression on T-lymphocytes (both on CD3CD8 and especially on CD3CD4 subsets) and HLA-DR expression on NK-lymphocytes (CD56+CD3-), increased levels of NKT-like cells (CD3+CD8+CD56+) but decreased levels of CD8 + NK lymphocytes compared to HCMV-seronegative patients. That difference was caused by significant numbers of individuals with deviated "accentuated" immune phenotypes in HCMV seropositive patients. The latter had increased (>7.5 %) levels of HLA-DR expression on T helpers in 136 cases from 419 (32.4 %) while in HCMV-seronegative group this accentuation was observed only in 3 of 51 patients (5.8 %), (OR -5.9, p < 0.0003). The number of cases with significantly increased CD56 expression on Tc lymphocytes, HLA-DR on NK and decrease of CD8-positive NK cells was more often observed in HCMV-seropositive group compared to seronegative. Thus, possibly HCMV seropositivity specifically influences immune system and results in pro-inflammatory phenotype formation in part of infected population. It was found that accentuations in immune phenotype of HCMV-seropositive women are very similar to previously described in association with reproductive failures but without HCMV serostatus taken into account.

中文翻译：

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在植入失败的女性中，HCMV血清反应阳性与特定的促炎免疫表型有关。

HCMV与人类共同发展了数百万年，现在已成为全世界最广泛的感染之一。长期以来，HCMV血清阳性被认为是安全的临床疾病。在最近的几十年中，临床观察和研究结果均表明，HCMV在人体中的存在特别影响免疫系统，并可能在很大程度上依赖于免疫细胞功能的过程中影响生殖。在470名符合IVF / ET资格的不育妇女中研究了抗HCMV IgG，IgG亲和力，淋巴细胞亚群以及NK细胞毒性。419例患者的IgG抗HCMV阳性（HCMV血清阳性），只有51例（10.8％）的IgG抗体抗HCMV阴性（HCMV血清阴性）。没有一例临床上低水平的IgG水平显着升高。HCMV血清反应阳性的患者T淋巴细胞（CD3CD8，尤其是CD3CD4亚群）的HLA-DR表达水平显着升高，NK淋巴细胞（CD56 + CD3-）的HLA-DR表达显着升高，NKT样细胞水平升高（CD3 + CD8 + CD56 +），但与HCMV血清阴性患者相比，CD8 + NK淋巴细胞水平降低。这种差异是由HCMV血清反应阳性患者中大量具有明显“突出”免疫表型的个体引起的。后者使136例T辅助者的HLA-DR表达水平从419例（32.4％）升高（> 7.5％），而在HCMV血清阴性组中，仅在51例患者中有3例（5.8％）观察到这种加重（OR -5.9，p <0.0003）。Tc淋巴细胞上CD56表达明显增加的病例数，与血清阴性相比，HCMV血清阳性组更常观察到NK上的HLA-DR和CD8阳性NK细胞的减少。因此，HCMV血清反应阳性可能会特异性影响免疫系统，并在部分感染人群中导致促炎表型的形成。已发现，HCMV血清反应阳性妇女的免疫表型增强与先前描述的与生殖衰竭有关，但未考虑HCMV血清状况非常相似。