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Multimodal visual exploration disturbances in Parkinson's disease detected with an infrared eye-movement assessment system
Neuroscience Research ( IF 2.9 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.neures.2019.11.003
Kou Nagai 1 , Yoshiyuki Kaneko 1 , Masahiro Suzuki 1 , Hiroko Teramoto 2 , Akihiko Morita 2 , Satoshi Kamei 2 , Yusuke Watanabe 3 , Masahiro Okada 4 , Makoto Uchiyama 1
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Parkinson's disease (PD) reportedly show disturbed visual exploration. However, whether this disturbance is due to dysfunctional visual information processing remains unclear. To clarify the effects of PD on visual information processing when exploring for targets and to compare disease effects with aging effects, we used an infrared eye-movement assessment system. Cognitively normal PD patients (n = 13), healthy age-matched (n = 17) and young controls (n = 36) participated in this study, and were evaluated using two figure-matching tasks representing visual information processing (clock-matching and inverted clock-matching tasks) and saccade tasks representing oculomotor function. With figure-matching tasks, PD patients showed significantly larger numbers of images watched in a single trial compared to healthy age-matched controls on the inverted clock-matching task. No aging effects was found in these variables. In contrast, no disease effect was apparent for reaction time, which was significantly longer in healthy age-matched controls than in healthy young controls. For saccade tasks, PD patients showed significantly smaller saccade size than healthy age-matched controls on the antisaccade task, but no aging effects were evident. Our approaches highlighted that visual exploration disturbance in PD may be due to dysfunctional visual information processing in addition to dysfunctional oculomotor processing. These disease effects may differ from aging effects.

中文翻译:

红外眼球运动评估系统检测帕金森病多模式视觉探索障碍

据报道,帕金森病 (PD) 表现出视觉探索障碍。然而,这种干扰是否是由于视觉信息处理功能障碍仍不清楚。为了在探索目标时阐明 PD 对视觉信息处理的影响,并将疾病影响与衰老影响进行比较,我们使用了红外眼动评估系统。认知正常的 PD 患者 (n = 13)、健康的年龄匹配 (n = 17) 和年轻对照 (n = 36) 参与了这项研究,并使用代表视觉信息处理的两个图形匹配任务(时钟匹配和倒时钟匹配任务)和代表动眼神经功能的扫视任务。通过人物匹配任务,与年龄匹配的健康对照组相比,PD 患者在单次试验中观看的图像数量显着增加。在这些变量中没有发现老化效应。相比之下,反应时间没有明显的疾病影响,健康年龄匹配的对照组明显长于健康的年轻对照组。对于扫视任务,PD 患者在反扫视任务中的扫视大小明显小于健康年龄匹配的对照组,但没有明显的老化效应。我们的方法强调了 PD 中的视觉探索障碍可能是由于视觉信息处理功能障碍以及动眼神经处理功能障碍所致。这些疾病影响可能与衰老影响不同。反应时间没有明显的疾病影响,健康年龄匹配的对照组明显长于健康的年轻对照组。对于扫视任务,PD 患者在反扫视任务中的扫视大小明显小于健康年龄匹配的对照组,但没有明显的老化效应。我们的方法强调了 PD 中的视觉探索障碍可能是由于视觉信息处理功能障碍以及动眼神经处理功能障碍所致。这些疾病影响可能与衰老影响不同。反应时间没有明显的疾病影响,健康年龄匹配的对照组明显长于健康的年轻对照组。对于扫视任务,PD 患者在反扫视任务中的扫视大小明显小于健康年龄匹配的对照组,但没有明显的老化效应。我们的方法强调了 PD 中的视觉探索障碍可能是由于视觉信息处理功能障碍以及动眼神经处理功能障碍所致。这些疾病影响可能与衰老影响不同。我们的方法强调了 PD 中的视觉探索障碍可能是由于视觉信息处理功能障碍以及动眼神经处理功能障碍所致。这些疾病影响可能与衰老影响不同。我们的方法强调了 PD 中的视觉探索障碍可能是由于视觉信息处理功能障碍以及动眼神经处理功能障碍所致。这些疾病影响可能与衰老影响不同。
更新日期:2020-11-01
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