Omega-3 fatty acids serve as the substrate for the formation of a group of lipid mediators that mediate the resolution of inflammation. The cardiovascular inflammatory response in atherosclerosis and vascular injury is characterized by a failure in the resolution of inflammation, resulting in a chronic inflammatory response. The proresolving lipid mediator resolvin E1 (RvE1) is formed by enzymatic conversion of the omega-3 fatty acid eicosapentaenoic acid (EPA), and signals resolution of inflammation through its receptor ChemR23. Importantly, the resolution of cardiovascular inflammation is an active, multifactorial process that involves modulation of the immune response, direct actions on the vascular wall, as well as close interactions between macrophages and vascular smooth muscle cells. Promoting anti-atherogenic signalling through the stimulation of endogenous resolution of inflammation pathways may provide a novel therapeutic strategy in cardiovascular prevention.

中文翻译：

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通过动脉粥样硬化，内膜增生和血管钙化中的omega-3脂肪酸解决炎症。

Omega-3脂肪酸作为形成一组脂质介体的底物，这些脂质介体调节炎症的消退。动脉粥样硬化和血管损伤中的心血管炎症反应的特征在于炎症消退失败，导致慢性炎症反应。前分解脂质介体resolvin E1（RvE1）是由ω-3脂肪酸二十碳五烯酸（EPA）的酶促转化形成的，并通过其受体ChemR23发出炎症消退的信号。重要的是，心血管炎症的解决是一个活跃的，多因素的过程，涉及免疫应答的调节，对血管壁的直接作用以及巨噬细胞和血管平滑肌细胞之间的紧密相互作用。