BACKGROUND Associations between polymorphisms in interleukins and tuberculosis (TB) susceptibility were already reported by many publications. The aim of this meta-analysis was to clarify associations between polymorphisms in interleukins and TB by combing the results of all relevant publications. METHODS Eligible publications were searched from Pubmed, Embase, WOS and CNKI. We used Review Manager to combine the results of individual studies. RESULTS Fifty-five studies were included in this study. IL-2 rs2069762 (recessive comparison), IL-4 rs2243250 (recessive and allele comparisons), IL-6 rs1800795 (dominant, recessive and allele comparisons), IL-8 rs4073 (dominant, recessive and allele comparisons), IL-10 rs1800871 (dominant, recessive and allele comparisons) and IL-10 rs1800896 (recessive comparison) polymorphisms were all significantly associated with TB in the total population. In subgroup analyses, we found positive results were mainly driven by the Asians. CONCLUSIONS Collectively, this meta-analysis proved that IL-2 rs2069762, IL-4 rs2243250, IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871 and IL-10 rs1800896 polymorphisms may confer susceptibility to TB, especially for Asians.

中文翻译：

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白细胞介素与结核多态性的关联：荟萃分析的证据。

背景技术许多出版物已经报道了白介素中的多态性与结核病（TB）敏感性之间的关联。这项荟萃分析的目的是通过结合所有相关出版物的结果来阐明白介素与结核病之间的多态性之间的关联。方法从Pubmed，Embase，WOS和CNKI中检索合格的出版物。我们使用“评论管理器”来组合单个研究的结果。结果该研究包括55项研究。IL-2 rs2069762（隐性比较），IL-4 rs2243250（隐性和等位基因比较），IL-6 rs1800795（显性，隐性和等位基因比较），IL-8 rs4073（显性，隐性和等位基因比较），IL-10 rs1800871 （优势，隐性和等位基因比较）和IL-10 rs1800896（隐性比较）多态性均与总人群中的TB显着相关。在亚组分析中，我们发现积极的结果主要是由亚洲人推动的。结论总体而言，该荟萃分析证明IL-2 rs2069762，IL-4 rs2243250，IL-6 rs1800795，IL-8 rs4073，IL-10 rs1800871和IL-10 rs1800896多态性可能使结核病易感性，尤其是对于亚洲人。