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Omega-3 polyunsaturated fatty acids have beneficial effects on visceral fat in diet-induced obesity model.
Biochemistry and Cell Biology ( IF 2.9 ) Pub Date : 2019-11-27 , DOI: 10.1139/bcb-2018-0361
Aline Haas de Mello 1 , Rosiane de Bona Schraiber 1 , Mariana Pereira de Souza Goldim 1 , Khiany Mathias 1 , Carolini Mendes 2 , Maria Eduarda Anastácio Borges Corrêa 2 , Maria Luiza Gomes 3 , Paulo Cesar Lock Silveira 2 , Patrícia Fernanda Schuck 4 , Fabricia Petronilho 1 , Gislaine Tezza Rezin 1
Affiliation  

This study evaluated the effects of omega-3 polyunsaturated fatty acids (PUFAs) on oxidative stress and energy metabolism parameters in the visceral fat of a high-fat-diet induced obesity model. Energy intake, body mass, and visceral fat mass were also evaluated. Male Swiss mice received either a control diet (control group) or a high-fat diet (obese group) for 6 weeks. After this period, the groups were divided into control + saline, control + omega-3, obese + saline, and obese + omega-3, and to these groups 400 mg·(kg body mass)-1·day-1 of fish oil (or saline) was administered orally, for 4 weeks. Energy intake and body mass were monitored throughout the experiment. In the 10th week, the animals were euthanized and the visceral fat (mesenteric) was removed. Treatment with omega-3 PUFAs did not affect energy intake or body mass, but it did reduced visceral fat mass. In visceral fat, omega-3 PUFAs reduced oxidative damage and alleviated changes to the antioxidant defense system and the Krebs cycle. The mitochondrial respiratory chain was neither altered by obesity nor by omega-3 PUFAs. In conclusion, omega-3 PUFAs have beneficial effects on the visceral fat of obese mice because they mitigate changes caused by the consumption of a high-fat diet.

中文翻译:

在饮食诱导的肥胖模型中,Omega-3多不饱和脂肪酸对内脏脂肪具有有益作用。

这项研究评估了omega-3多不饱和脂肪酸(PUFAs)对高脂饮食诱导的肥胖模型内脏脂肪中氧化应激和能量代谢参数的影响。还评估了能量摄入,体重和内脏脂肪量。雄性瑞士小鼠接受对照饮食(对照组)或高脂饮食(肥胖组),持续6周。在此期间之后,将各组分为对照组+盐水,对照组+ omega-3,肥胖+盐水和肥胖+ omega-3,并向这些组中添加400 mg·(kg体重)-1·day-1的鱼口服油(或盐水)4周。在整个实验过程中监测能量摄入和体重。在第10周,对动物实施安乐死并去除内脏脂肪(肠系膜)。使用omega-3 PUFA进行治疗不会影响能量摄入或体重,但它确实减少了内脏脂肪量。在内脏脂肪中,omega-3 PUFA减少了氧化损伤并减轻了抗氧化防御系统和克雷布斯循环的变化。肥胖或omega-3 PUFA均不会改变线粒体呼吸链。总之,omega-3 PUFA对肥胖小鼠的内脏脂肪具有有益的作用,因为它们可以减轻因食用高脂饮食而引起的变化。
更新日期:2019-11-01
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