Glutathione S-transferases (GST) are antioxidant enzymes with frequent genetic polymorphisms. Homozygosis for gene deletion ("null" genotype) of GSTM1 and GSTT1, causing decrease of the antioxidant potential of the organism, is frequent, with variable frequency in different ethnic contexts. Although oxidative stress notoriously plays a role in the pathogenesis of psoriasis, few studies exist on the association between GSTM1/GSTT1 genotype and psoriasis, with different results. We aimed to assess the frequency of GSTM1/GSTT1 polymorphisms in Southern Italian psoriatic patients and controls and investigate the association of the GSTM1/GSTT1 genotype with individual and disease parameters. To this aim, the GSTM1/GSTT1 genotype of 148 psoriatic patients and 148 age- and sex-matched controls was defined by PCR on oral mucosa cells. GSTT1 null was associated with psoriasis (55.4% of patients vs. 25% of controls, p = 9.58 × 10-8, odds ratio 3.73), while GSTM1 null was not. The GSTM1/GSTT1 "double null" genotype conferred an even higher odds ratio for psoriasis (5.94). The association between psoriasis and GSTT1 null was stronger in women (54.1% of patients vs. 19.7% of controls, p = 8.13 × 10-5) than in men (56.3% of patients vs. 28.7% of controls, p = 0.0002). No association was found between GSTM1/GSTT1 genotype and psoriasis severity, age of onset or comorbidities (psoriatic arthritis, metabolic syndrome). The remarkable differences among the few available data on the association between GSTM1/GSTT1 polymorphisms and psoriasis suggest the need for further studies, on different and larger populations, to improve knowledge on the pathogenesis of psoriasis and possibly provide more precise and personalised prevention and treatment in the future.

中文翻译：

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谷胱甘肽S-转移酶M1 / T1的遗传多态性与牛皮癣（意大利南部）人群中的牛皮癣之间的关联。

谷胱甘肽S-转移酶（GST）是具有常见遗传多态性的抗氧化酶。GSTM1和GSTT1的基因缺失（“无效”基因型）的纯合，导致生物体抗氧化能力降低，是很常见的，在不同种族背景下发生频率可变。尽管氧化应激在牛皮癣的发病机理中起着举足轻重的作用，但关于GSTM1 / GSTT1基因型与牛皮癣之间关系的研究很少，结果却不同。我们旨在评估意大利南部银屑病患者和对照中GSTM1 / GSTT1多态性的频率，并研究GSTM1 / GSTT1基因型与个体和疾病参数的关联。为了这个目的，通过PCR在口腔粘膜细胞上确定了148例牛皮癣患者和148例年龄和性别匹配的对照的GSTM1 / GSTT1基因型。GSTT1无效与银屑病相关（55.4％的患者与25％的对照组，p = 9.58×10-8，比值比3.73），而GSTM1无效与牛皮癣相关。GSTM1 / GSTT1“双无效”基因型赋予牛皮癣更高的优势比（5.94）。女性（54.1％的患者与对照组的19.7％，p = 8.13×10-5）比男性（56.3％的患者与对照组的28.7％，p = 0.0002）的银屑病与GSTT1无相关性更强。 。在GSTM1 / GSTT1基因型与牛皮癣严重程度，发病年龄或合并症（银屑病关节炎，代谢综合征）之间未发现关联。关于GSTM1 / GSTT1多态性与银屑病之间关联性的少数可用数据之间的显着差异表明，有必要对不同和更大的人群进行进一步研究，