Psoriatic arthritis (PsA) is an inflammatory arthritis with distinct phenotypic subtypes. Enthesitis is assigned as a hallmark of the disease, given its significant relations to disease activity and quality of life. Our objective is to evaluate the prevalence of enthesitis and its association with some clinical parameters, particularly quality of life, using data from a national registry. Patients with PsA meeting ClASsification criteria for Psoriatic Arthritis (CASPAR) were enrolled by means of a multi-centre Turkish League Against Rheumatism (TLAR) Network Project. The following information was recorded in web-based case report forms: demographic, clinical and radiographic data; physical examination findings, including tender and swollen joint counts (TJC and SJC); nail and skin involvement; Disease Activity Score-28 for Rheumatoid Arthritis with Erythrocyte Sedimentation Rate (DAS 28-ESR); Bath Ankylosing Spondylitis Disease Activity Index (BASDAI); Maastricht Ankylosing Spondylitis Enthesitis Score (MASES); Psoriasis Area Severity Index (PASI); Bath Ankylosing Spondylitis Radiology Index for the spine (BASRI-s); Health Assessment Questionnaire (HAQ); Bath Ankylosing Spondylitis Functional Index (BASFI); Health Assessment Questionnaire for the spondyloarthropathies (HAQ-s); Psoriatic arthritis quality of Life scale (PsAQoL); Short Form 36 (SF-36); Hospital Anxiety Depression Scale (HADS); Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F); and Fibromyalgia Rapid Screening Tool (FiRST) scores. The patients were divided into two groups, namely with and without enthesitis, based on the triple Likert-type physician-reported statement of 'active enthesitis', 'history of enthesitis' or 'none' in the case report forms. Patients with active enthesitis were compared to others in terms of these clinical parameters. A total of 1130 patients were enrolled in this observational study. Of these patients, 251 (22.2%) had active enthesitis according to the clinical assessment. TJC, HAQ-s, BASDAI, FiRST and PsAQoL were significantly higher whereas the SF-36 scores were lower in patients with enthesitis (p < 0.05). Chronic back pain, dactylitis, and tenosynovitis were more frequent in the enthesopathy group (59.4%/39%, 13.1%/6.5% and 24.7%/3.4%, respectively). Significant positive correlations between the MASES score and the TJC, HAQ, DAS 28-ESR, BASDAI, FiRST and PsAQoL scores, and a negative correlation with the SF-36 score were found. When linear regression analysis was performed, the SF-36 MCS and PCS scores decreased by - 9.740 and - 11.795 units, and the FiRST scores increased by 1.223 units in patients with enthesitis. Enthesitis is an important involvement of PsA with significant relations to quality of life determined with PsAQoL and SF-36 scores. Our study found higher frequency of dactylitis and chronic back pain, and worse quality of life determined with SF-36 and PsAQoL scores in patients with enthesitis.

中文翻译：

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银屑病关节炎中的脑炎及其与疾病活动，功能状态和生活质量的关系：一项多中心研究。

银屑病关节炎（PsA）是一种具有明显表型亚型的炎性关节炎。鉴于其与疾病活动和生活质量的显着关系，因此将其定义为该疾病的标志。我们的目标是使用国家注册中心的数据评估肠炎的患病率及其与某些临床参数（尤其是生活质量）的关联。通过多中心土耳其抗风湿病联盟（TLAR）网络项目，招募了符合牛皮癣性关节炎ClASsification标准的PsA患者（CASPAR）。以下信息记录在基于Web的病例报告表中：人口统计学，临床和射线照相数据；体格检查结果，包括关节压痛和肿胀（TJC和SJC）；指甲和皮肤受累；类风湿关节炎伴有红细胞沉降率的疾病活动评分-28（DAS 28-ESR）；巴斯强直性脊柱炎疾病活动指数（BASDAI）；马斯特里赫特强直性脊柱炎脑炎评分（MASES）；牛皮癣区域严重程度指数（PASI）；脊柱浴强直性脊柱炎放射学指数（BASRI-s）；健康评估问卷（HAQ）；沐浴强直性脊柱炎功能指数（BASFI）；脊椎病健康评估问卷（HAQ-s）；银屑病关节炎生活质量量表（PsAQoL）；简式36（SF-36）; 医院焦虑抑郁量表（HADS）；慢性病疲劳治疗功能评估（FACIT-F）；和纤维肌痛快速筛查工具（FiRST）得分。将患者分为两组，即有和没有肠炎，根据病例报告表中三重李克特型医师报告的“活动性肠炎”，“病史”或“无”的陈述。在这些临床参数方面，将活动性肠炎患者与其他患者进行了比较。这项观察性研究共招募了1130名患者。根据临床评估，在这些患者中，有251名（22.2％）患有活动性肠炎。肠炎患者的TJC，HAQ-s，BASDAI，FiRST和PsAQoL显着较高，而SF-36评分则较低（p <0.05）。肠病组的慢性背痛，齿根炎和腱鞘炎更为常见（分别为59.4％/ 39％，13.1％/ 6.5％和24.7％/ 3.4％）。MASES得分与TJC，HAQ，DAS 28-ESR，BASDAI，FiRST和PsAQoL得分之间呈显着正相关，发现与SF-36得分呈负相关。进行线性回归分析时，脑炎患者的SF-36 MCS和PCS评分降低了-9.740和-11.795单位，而FIRST评分提高了1.223单位。乙型脑炎是PsA的重要疾病，与PsAQoL和SF-36评分确定的生活质量密切相关。我们的研究发现，患有肠炎的患者使用SF-36和PsAQoL评分可得出较高的乳腺炎和慢性背痛以及较差的生活质量。乙型脑炎是PsA的重要疾病，与PsAQoL和SF-36评分确定的生活质量密切相关。我们的研究发现，患有肠炎的患者使用SF-36和PsAQoL评分可得出较高的乳腺炎和慢性背痛以及较差的生活质量。乙型脑炎是PsA的重要疾病，与PsAQoL和SF-36评分确定的生活质量密切相关。我们的研究发现，患有肠炎的患者使用SF-36和PsAQoL评分可得出较高的乳腺炎和慢性背痛以及较差的生活质量。