BACKGROUND Little is known about the endoscopic and histologic findings of non-esophageal eosinophilic gastrointestinal diseases (EGID). AIM To characterize the presenting endoscopic and histologic findings in patients with eosinophilic gastritis (EG), eosinophilic gastroenteritis (EGE), and eosinophilic colitis (EC) at diagnosis and 6 months after initiating the treatment. METHODS We conducted a retrospective cohort study at 6 US centers associated with the Consortium of Eosinophilic Gastrointestinal Researchers. Data abstracted included demographics, endoscopic findings, tissue eosinophil counts, and associated histologic findings at diagnosis and, when available, after initial treatment. RESULTS Of 373 subjects (317 children and 56 adults), 142 had EG, 123 EGE, and 108 EC. Normal endoscopic appearance was the most common finding across all EGIDs (62% of subjects). Baseline tissue eosinophil counts were quantified in 105 (74%) EG, 36 (29%) EGE, and 80 (74%) EC subjects. The mean peak gastric eosinophil count across all sites was 87 eos/hpf for EG and 78 eos/hpf for EGE. The mean peak colonic eosinophil count for EC subjects was 76 eos/hpf (range 10-500). Of the 29% of subjects with post-treatment follow-up, most had an improvement in clinical, endoscopic, and histologic findings regardless of treatment utilized. Reductions in tissue eosinophilia correlated with improvements in clinical symptoms as well as endoscopic and histologic findings. CONCLUSIONS In this large cohort, normal appearance was the most common endoscopic finding, emphasizing the importance of biopsy, regardless of endoscopic appearance. Decreased tissue eosinophilia was associated with improvement in symptoms, endoscopic, and histologic findings, showing that disease activity is reversible.

中文翻译：

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非食道嗜酸性粒细胞胃肠道疾病患者多中心回顾性队列中内镜和组织学结果之间的关联。

背景对非食管嗜酸性粒细胞胃肠疾病（EGID）的内窥镜和组织学发现知之甚少。目的 描述嗜酸性粒细胞性胃炎 (EG)、嗜酸性粒细胞性胃肠炎 (EGE) 和嗜酸性粒细胞性结肠炎 (EC) 患者在诊断时和开始治疗后 6 个月的内镜和组织学表现。方法 我们在与嗜酸性胃肠道研究人员联盟相关的 6 个美国中心进行了一项回顾性队列研究。提取的数据包括人口统计学、内窥镜检查结果、组织嗜酸性粒细胞计数以及诊断时和初始治疗后的相关组织学发现。结果 在 373 名受试者（317 名儿童和 56 名成人）中，142 名患有 EG、123 名 EGE 和 108 名 EC。正常的内窥镜外观是所有 EGID 中最常见的发现（62% 的受试者）。在 105 (74%) 名 EG、36 (29%) 名 EGE 和 80 (74%) 名 EC 受试者中量化了基线组织嗜酸性粒细胞计数。所有部位的平均峰值胃嗜酸性粒细胞计数为 EG 的 87 eos/hpf 和 EGE 的 78 eos/hpf。EC 受试者的平均峰值结肠嗜酸性粒细胞计数为 76 eos/hpf（范围 10-500）。在接受治疗后随访的 29% 受试者中，无论采用何种治疗方法，大多数受试者的临床、内窥镜和组织学发现都有所改善。组织嗜酸性粒细胞增多的减少与临床症状以及内窥镜和组织学发现的改善相关。结论 在这个大型队列中，正常外观是最常见的内镜检查结果，强调了活检的重要性，无论内镜外观如何。