In the last 15 years, Acinetobacter baumannii has received special attention, mainly due to several resistance mechanisms and high rates of morbimortality. The ability to form biofilms contributes to the persistence of this microorganism in the hospital environment and facilitates the occurrence of nosocomial infections. Several studies have highlighted the pharmacological relevance of pyridines in the treatment and control of infectious diseases and others have related the anti-A. baumannii potential of hydrazine derivatives. Considering this scenario, we aimed to evaluate the antimicrobial and antibiofilm activity of 10 pyridinylhydrazone compounds against A. baumannii. The minimum inhibitory concentration of the compounds was determined by broth microdilution method and the antibiofilm activity was evaluated by inhibition and destruction biofilm assays. In addition, the cytotoxicity of the compounds in the J774A.1 cell line was also evaluated, and the selectivity index was calculated. Among the 10 pyridine compounds, the compounds B and D were able to inhibit the formation of biofilms and destroy bacterial biofilms even in a concentration of 12.5 μg/mL. Thus, the pyridine compounds evaluated can be a scaffold for the development of new substances with antimicrobial and antibiofilm activity.

中文翻译：

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芳烃甲醛 2-吡啶基腙衍生物对鲍曼不动杆菌的抗生物膜潜力。

在过去的 15 年中，鲍曼不动杆菌受到了特别的关注，主要是由于多种耐药机制和高死亡率。形成生物膜的能力有助于这种微生物在医院环境中的持续存在并促进医院感染的发生。一些研究强调了吡啶在治疗和控制传染病方面的药理学相关性，而其他研究则与肼衍生物的抗鲍曼不动杆菌潜力相关。考虑到这种情况，我们旨在评估 10 种吡啶基腙化合物对鲍曼不动杆菌的抗菌和抗生物膜活性. 通过肉汤微量稀释法测定化合物的最小抑制浓度，通过抑制和破坏生物膜试验评价抗生物膜活性。此外，还评估了化合物在J774A.1细胞系中的细胞毒性，并计算了选择性指数。在10种吡啶化合物中，化合物B和D即使在12.5 μg/mL的浓度下也能抑制生物膜的形成并破坏细菌生物膜。因此，所评估的吡啶化合物可以作为开发具有抗菌和抗生物膜活性的新物质的支架。