Efficacy of the Leptospira components of multivalent vaccine DAPPi-L was previously demonstrated against virulent challenge with three serovars of Leptospira interrogans (Canicola, Icterohaemorrhagiae and Grippotyphosa) carried out 14 days after primary vaccination. In this study we demonstrate that this vaccine provides, two weeks after vaccination, an additional protection (prevention of mortality, clinical signs, renal infection, bacterial excretion, renal carriage and renal lesions) against fatal leptospirosis due to Leptospira interrogans serovar Copenhageni (serovar of major medical importance).

中文翻译：

---

对抗钩端螺旋体出血性出血热，Canicola和Grippotyphosa的犬用疫苗可提供针对钩端螺旋体血清型Copenhageni的交叉保护。

先前已证明，初次接种疫苗后14天对三种血清型钩端螺旋体问号（Canicola，Icterohaemorrhagiae和Grippotyphosa）进行了多价疫苗DAPPi-L钩端螺旋体成分对抗强毒攻击的功效。在这项研究中，我们证明了该疫苗在接种后两周提供了额外的保护（预防死亡率，临床体征，肾脏感染，细菌排泄，肾脏运输和肾脏损害），以防止因问号钩端螺旋体血清型哥本哈根病毒引起的致命钩端螺旋体病。重要的医学重要性）。