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Anti-Alzheimer's Materials Isolated from Marine Bio-resources: A Review.
Current Alzheimer Research ( IF 2.1 ) Pub Date : 2019-01-01 , DOI: 10.2174/1567205016666191024144044
Anuruddhika Udayangani Rathnayake 1 , Racheal Abuine 1 , Yong-Jae Kim 1 , Hee-Guk Byun 1
Affiliation  

The most common type of dementia found in the elderly population is Alzheimer's disease. The disease not only impacts the patients and their families but also the society therefore, the main focus of researchers is to search new bioactive materials for treating AD. The marine environment is a rich source of functional ingredients and to date, we can find sufficient research relating to anti- Alzheimer's compounds isolated from marine environment. Therefore, this review focuses on the anti- Alzheimer's material from marine bio-resources and then expounds on the anti-Alzheimer's compounds from marine seaweed, marine animal and marine microorganisms. Moreover, because of the complexity of the disease, different hypothesizes have been elaborated and active compounds have been isolated to inhibit different stages of pathophysiological mechanisms. Sulfated polysaccharides, glycoprotein, and enzymatic hydrolysates from marine seaweeds, peptides, dietary omega-3 polyunsaturated fatty acids and skeletal polysaccharide from marine animals and secondary metabolites from marine microorganism are summarized in this review under the anti-Alzheimer's compounds from the marine.

中文翻译:

从海洋生物资源中分离出的抗阿尔茨海默氏病材料:综述。

在老年人口中发现的最常见的痴呆类型是阿尔茨海默氏病。该病不仅影响患者及其家人,而且影响整个社会,因此,研究人员的主要重点是寻找治疗AD的新生物活性材料。海洋环境是功能成分的丰富来源,迄今为止,我们可以找到与从海洋环境中分离出的抗阿尔茨海默氏病化合物有关的充分研究。因此,本综述着重于海洋生物资源中的抗阿尔茨海默氏病物质,然后阐述了海洋海藻,海洋动物和海洋微生物中的抗阿尔茨海默氏病化合物。而且,由于这种疾病的复杂性,已经阐明了不同的假设,并且已经分离了活性化合物以抑制病理生理机制的不同阶段。本综述总结了海洋动物的硫酸化多糖,糖蛋白和海洋藻类的酶水解产物,海洋动物的肽,饮食中的ω-3多不饱和脂肪酸和骨架多糖以及海洋微生物的次生代谢产物,这些物质是来自海洋的抗阿尔茨海默氏病化合物。
更新日期:2019-11-01
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