Breast cancer is the most common malignancy in women all over the world. Genetic background of women contributes to her risk of having breast cancer. Certain inherited DNA mutations can dramatically increase the risk of developing certain cancers and are responsible for many of the cancers that run in some families. Regarding the widespread multigene panels, whole exome sequencing is capable of providing the evaluation of genetic function mutations for development novel strategy in clinical trials. Targeting the mutant proteins involved in breast cancer can be an effective therapeutic approach for developing novel drugs. This systematic review discusses gene mutations linked to breast cancer, focusing on signaling pathways that are being targeted with investigational therapeutic strategies, where clinical trials could be potentially initiated in the future are being highlighted.

中文翻译：

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基于乳腺癌分子特征的治疗靶点的最新进展：基因突变以及对当前治疗范式的影响。

乳腺癌是全世界女性最常见的恶性肿瘤。女性的遗传背景会增加患乳腺癌的风险。某些遗传性 DNA 突变会显着增加患某些癌症的风险，并且是某些家族中遗传的许多癌症的原因。对于广泛的多基因组，全外显子组测序能够提供遗传功能突变的评估，以开发临床试验中的新策略。针对乳腺癌中涉及的突变蛋白可能是开发新药的有效治疗方法。这篇系统综述讨论了与乳腺癌相关的基因突变，重点关注研究性治疗策略所针对的信号通路，并强调了未来可能启动的临床试验。