Burkholderia cepacia complex (Bcc) are opportunistic pathogens implicated with nosocomial infections, and high rates of morbidity and mortality, especially in individuals with cystic fibrosis (CF). B. cepacia are naturally resistant to different classes of antibiotics, and can subvert the host innate immune responses by producing quorum sensing (QS) controlled virulence factors and biofilms. It still remains a conundrum as to how exactly the bacterium survives the intracellular environment within the host cells of CF patients and immunocompromised individuals although the bacterium can invade human lung epithelial cells, neutrophils, and murine macrophages. The mechanisms associated with intracellular survival in the airway epithelial cells and the role of QS and virulence factors in B. cepacia infections in cystic fibrosis remain largely unclear. The current review focuses on understanding the role of QS-controlled virulence factors and biofilms, and provides additional impetus to understanding the potentials of QS-inhibitory strategies against B. cepacia.

中文翻译：

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洋葱伯克霍尔德菌的细胞内存活和先天性免疫逃避：更好地了解群体感应控制的毒力因子，生物膜和抑制剂。

伯克霍尔德菌洋葱伯克霍尔德菌（Bccholderia cepacia complex）（Bcc）是机会病原体，与医院感染有关，发病率和死亡率高，特别是在患有囊性纤维化（CF）的个体中。洋葱伯克霍尔德菌对不同种类的抗生素具有天然抗性，并且可以通过产生群体感应（QS）控制的毒力因子和生物膜来破坏宿主固有的免疫反应。尽管该细菌可以侵袭人肺上皮细胞，嗜中性粒细胞和鼠巨噬细胞，但在CF患者和免疫受损的个体的宿主细胞内如何在细胞内环境中生存仍然是一个难题。在气道上皮细胞中与细胞内存活相关的机制以及囊性纤维化中洋葱伯克氏菌感染中QS和毒力因子的作用仍不清楚。