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Gingerol inhibits cisplatin-induced acute and delayed emesis in rats and minks by regulating the central and peripheral 5-HT, SP, and DA systems.
Journal of Natural Medicines ( IF 3.3 ) Pub Date : 2019-11-25 , DOI: 10.1007/s11418-019-01372-x
Li Tian 1 , Weibin Qian 2, 3 , Qiuhai Qian 4 , Wei Zhang 3 , Xinrui Cai 5
Affiliation  

Abstract

Gingerol, a biologically active component in ginger, has shown antiemetic properties. Our study aimed to explore the underlying mechanisms of gingerol on protecting rats and minks from chemotherapy-induced nausea and vomiting. The preventive impact of gingerol was evaluated in the pica model of rats and the vomiting model of minks induced by cisplatin at every 6 h continuously for a duration of 72 h. Animals were arbitrarily separated into blank control group, simple gingerol control group, cisplatin control group, cisplatin + metoclopramide group, cisplatin + three different doses gingerol group (low-dose; middle-dose; high-dose). The area postrema as well as ileum damage were assessed using H&E stain. The levels of 5-TH, 5-HT3 receptor, TPH, SERT, SP, NK1 receptor, PPT, NEP, DA, D2R, TH, and DAT were determined using immunohistochemistry or qRT-PCR in rats and minks. All indicators were measured in the area postrema along with ileum. The kaolin intake by rats and the incidence of CINV of minks were significantly decreased after pretreatment with gingerol in a dosage-dependent way for the duration of 0–24-h and 24–72-h. Gingerol markedly decreased the levels of 5-TH, 5-HT3 receptor, TPH, SP, NK1 receptor, PPT, DA, D2R, TH, alleviated area postrema as well as ileum damage, and increased the accumulation of SERT, NEP, DAT in the area postrema along with ileum of rats and minks. Gingerol alleviates cisplatin-induced kaolin intake of rats and emesis of minks possibly by regulating central and peripheral 5-HT system, SP system and DA system.

Graphic abstract



中文翻译:

姜油通过调节中枢和外周5-HT,SP和DA系统抑制顺铂诱导的大鼠和貂的急性和延迟呕吐。

摘要

生姜中的一种生物活性成分-生姜具有止吐作用。我们的研究旨在探讨姜黄素保护大鼠和貂皮免受化学疗法诱发的恶心和呕吐的潜在机制。在大鼠的异食癖模型和顺铂诱导的水貂呕吐模型中,每隔6小时连续评估72h姜黄素的预防作用。将动物任意分为空白对照组,简单姜醇对照组,顺铂对照组,顺铂+甲氧氯普胺组,顺铂+三种不同剂量的姜醇组(低剂量;中剂量;高剂量)。使用H&E染色评估术后区域和回肠损伤。5-TH,5-HT 3受体,TPH,SERT,SP,NK 1的水平使用免疫组织化学或qRT-PCR测定大鼠和貂的受体,PPT,NEP,DA,D2R,TH和DAT。所有指标均在回肠区域和回肠测量。在0–24-h和24-72-h的时间内,用姜黄素预处理后,大鼠的高岭土摄入量和貂的CINV发生率显着降低。姜油显着降低了5-TH,5-HT 3受体,TPH,SP,NK 1的水平受体,PPT,DA,D2R,TH减轻了视网膜后区域以及回肠的损害,并增加了大鼠和貂皮回肠后区域SERT,NEP,DAT的积累。姜油可能通过调节中枢和外周5-HT系统,SP系统和DA系统来减轻顺铂诱导的大鼠高岭土摄入和水貂呕吐。

图形摘要

更新日期:2019-11-25
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