Neutrophils are produced in the bone marrow and then patrol blood vessels from which they can be rapidly recruited to a site of infection. Neutrophils bind, engulf, and efficiently kill invading microbes via a suite of defense mechanisms. Diverse extracellular and intracellular microbes induce neutrophils to extrude neutrophil extracellular traps (NETs) through the process of NETosis. Here, we review the signaling mechanisms and cell biology underpinning the key NETosis pathways during infection and the antimicrobial functions of NETs in host defense.

中文翻译：

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宿主防御中的中性粒细胞胞外陷阱。

中性粒细胞在骨髓中产生，然后在血管中巡逻，从中可以迅速将它们募集到感染部位。中性粒细胞通过一套防御机制结合、吞噬并有效杀死入侵的微生物。不同的细胞外和细胞内微生物通过 NETosis 过程诱导中性粒细胞挤出中性粒细胞胞外陷阱 (NETs)。在这里，我们回顾了感染期间支持关键 NETosis 途径的信号机制和细胞生物学以及 NET 在宿主防御中的抗菌功能。