The present study was conducted to investigate the effects of dietary supplementation of selenium from different sources on the growth performance, nutrient digestibility, and blood immune indices of piglets orally challenged with Salmonella typhimurium (ST). In a 2 × 2 factorial arrangement, 32 piglets (6.43 ± 0.54 kg of body mass) were assigned into four groups with or without dietary inclusion of sodium selenite (SS) or yeast selenium (YS) and with or without ST challenge (5 ml 1 × 109 cfu/ml ST or 5 ml saline) on d 13. In each period, YS increased average daily feed intake and average daily gain but did not reach statistical significance. During the challenged stage, piglets fed YS had higher digestibility of dry matter, crude protein, crude fat, and YS reduced the amount of Escherichia coli in feces. Additionally, YS regulated the composition of T-lymphocyte subset and influenced the production of inflammatory cytokines. In conclusion, in this study selenium-enriched yeast was more effective in enhancing nutrient digestibility, and inhibiting inflammation and oxidative stress by inducing the activity of the lymphocytes, expression of antioxidant enzymes and so on.

中文翻译：

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酵母硒与亚硒酸钠对鼠伤寒沙门氏菌挑战的断奶仔猪生长性能，养分消化率，抗炎和抗氧化活性的比较研究。

本研究旨在研究饮食中补充不同来源硒对口服鼠伤寒沙门氏菌（ST）攻击的仔猪的生长性能，营养消化率和血液免疫指标的影响。在2×2因子布置中，将32头仔猪（6.43±0.54 kg体重）分为四组，有或没有饮食中添加亚硒酸钠（SS）或酵母硒（YS），有或没有ST挑战（5 ml在第13天，YS增加1×109 cfu / ml ST或5 ml生理盐水。在每个时期，YS增加平均日采食量和平均日增重，但未达到统计学意义。在激发阶段，饲喂YS的仔猪对干物质，粗蛋白，粗脂肪的消化率更高，YS减少了粪便中大肠杆菌的含量。另外，YS调节T淋巴细胞亚群的组成并影响炎性细胞因子的产生。总之，在这项研究中，富硒酵母通过诱导淋巴细胞的活性，抗氧化酶的表达等，在增强营养物质的消化率，抑制炎症和氧化应激方面更有效。