From a clinical perspective, there is a need for a reliable and comprehensive list of diseases causing AA amyloidosis. This list could guide clinicians in the evaluation of patients with AA amyloidosis in whom an obvious cause is lacking. In this systematic review, a PubMed, Embase and Web of Science literature search were performed on causes of AA amyloidosis published in the last four decades. Initially, 4066 unique titles were identified, but only 795 full-text articles and letters were finally selected for analysis. Titles were excluded because of non-AA type of amyloidosis, language, no full-text publication or irrelevance. Hundred and fifty diseases were initially reported to be associated with the development of AA amyloidosis. The presence of AA amyloid was proven in 208 articles (26% of all) of which 140 (67%) showed a strong association with an underlying disease process. Disease associations were categorized and 48 were listed as strong, 19 as weak, 23 as unclear, and 60 as unlikely. Most newly described diseases are not really unexpected because they often cause longstanding inflammation. Based on the spectrum of identified causes, a pragmatic diagnostic approach is proposed for the AA amyloidosis patient in whom an obvious underlying disease is lacking.

中文翻译：

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AA淀粉样变性病的原因：系统评价。

从临床观点来看，需要可靠和全面的引起AA淀粉样变性病的疾病清单。该清单可以指导临床医生评估缺乏明显原因的AA淀粉样变性患者。在这项系统评价中，对过去四十年发表的AA淀粉样变性病的病因进行了PubMed，Embase和Web of Science文献检索。最初，确定了4066个唯一标题，但最终只选择了795个全文文章和字母进行分析。由于非AA型淀粉样变性病，语言，没有全文发表或不相关，因此标题被排除在外。最初有一百五十种疾病与AA淀粉样变性病的发展有关。208篇文章（占总数的26％）证明了AA淀粉样蛋白的存在，其中140篇（67％）与潜在的疾病过程密切相关。对疾病协会进行了分类，其中强者48例，弱者19例，不清楚者23例，不可能者60例。多数新近描述的疾病并不是真正出乎意料的，因为它们通常会引起长期的炎症。基于已查明原因的范围，针对缺乏明显基础疾病的AA淀粉样变性病患者，提出了一种实用的诊断方法。