ABSTRACT Biomechanical properties of soft tissues are important indicators of tissue functions which can be used for clinical diagnosis and disease monitoring. Elastography, incorporating the principles of elasticity measurements into imaging modalities, provides quantitative assessment of elastic properties of biological tissues. Benefiting from high-resolution, noninvasive, and three-dimensional optical coherence tomography, optical coherence elastography (OCE) is an emerging optical imaging modality to characterize and map biomechanical properties of soft tissues. Recently, acoustic radiation force (ARF)–OCE has been developed for elasticity measurements of ocular tissues, detection of vascular lesions, and monitoring of blood coagulation based on remote and noninvasive ARF excitation to both internal and superficial tissues. Here, we describe the advantages of the ARF–OCE technique, the measurement methods in ARF–OCE, the applications in biomedical detection, current challenges, and advances. ARF–OCE technology has the potential to become a powerful tool for in vivo elasticity assessment of biological samples in a noncontact, noninvasive, and high-resolution nature.

中文翻译：

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用于软组织弹性评估的声辐射力光学相干弹性成像

摘要 软组织的生物力学特性是组织功能的重要指标，可用于临床诊断和疾病监测。弹性成像将弹性测量的原理结合到成像模式中，提供生物组织弹性特性的定量评估。受益于高分辨率、无创和三维光学相干断层扫描，光学相干弹性成像 (OCE) 是一种新兴的光学成像方式，用于表征和绘制软组织的生物力学特性。最近，声辐射力 (ARF)-OCE 已被开发用于眼组织的弹性测量、血管病变的检测以及基于对内部和表面组织的远程和非侵入性 ARF 激发的血液凝固监测。这里，我们描述了 ARF-OCE 技术的优势、ARF-OCE 中的测量方法、生物医学检测中的应用、当前的挑战和进展。ARF-OCE 技术有可能成为一种强大的工具，用于以非接触、非侵入性和高分辨率对生物样品进行体内弹性评估。