Here, I present the data testifying that the conversion of free radical NO molecules to nitrosonium ions (NO⁺), which are necessary for the realization of one of NO biological effects (S-nitrosation), may occur in living organisms after binding NO molecules to loosely bound iron (Fe²⁺ ions) with the subsequent mutual one-electron oxidation–reduction of NO molecules (their disproportionation). Inclusion of thiol-containing substances as iron ligands into this process prevents hydrolysis of NO⁺ ions bound to iron thus providing the formation of stable dinitrosyl iron complexes (DNIC) with thiol ligands. Such complexes act in living organisms as donors of NO and NO⁺, providing stabilization and transfer of these agents via the autocrine and paracrine pathways. Without loosely bound iron (labile iron pool) and thiols participating in the DNIC formation, NO functioning as one of universal regulators of diverse metabolic processes would be impossible.

中文翻译：

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一氧化氮转化为氮离子的机制是什么，以确保生物体内的S-亚硝化过程。

在这里，我提供的数据证明，结合NO分子后，活生物体中可能会发生自由基NO分子向亚硝基离子（NO ⁺）转化的现象，这是实现NO生物学效应之一（S-亚硝化）所必需的。到松散结合的铁（Fe ²⁺离子）上，随后相互进行单电子氧化-还原NO分子（它们的歧化）。在此过程中包含含硫醇的物质作为铁配体可防止与铁结合的NO ⁺离子水解，从而形成具有硫醇配体的稳定的二亚硝酰基铁络合物（DNIC）。这些络合物在生物体中充当NO和NO ^+的供体通过自分泌和旁分泌途径提供这些药物的稳定和转移。如果没有松散结合的铁（不稳定的铁池）和硫醇参与DNIC的形成，则NO不可能充当各种代谢过程的通用调节剂之一。